[PDF][PDF] Editorial. Drug-induced hepatotoxicity

FP Busardò, A Grieco - Eur Rev Med Pharmacol Sci, 2017 - europeanreview.org
Paracetamol is the most commonly used antipyretic and pain reliever. Paracetamol
overdoses are the leading cause of acute poisoning in the United States and represent …

[PDF][PDF] Medicines Safety Update

AM Larson, J Polson, RF Fontana, TJ Davern, E Lalani… - Hepatology, 2005 - nps.org.au
In many patients with hepatotoxicity, the paracetamol was taken for therapeutic purposes
only. In a study of 662 patients with severe paracetamolinduced hepatotoxicity, 48% had not …

Drug-induced liver injury: what was new in 2013?

WM Chalhoub, KD Sliman… - Expert Opinion on …, 2014 - Taylor & Francis
Introduction: The year 2013 continued to highlight numerous aspects of drug-induced liver
injury (DILI), with new information communicated via> 1500 publications. New reports of DILI …

Emerging novel therapies against paracetamol (acetaminophen) hepatotoxicity

H Jaeschke - EBioMedicine, 2019 - thelancet.com
Paracetamol (acetaminophen) is a popular analgesic and antipyretic drug used worldwide. It
is generally considered safe at therapeutic doses. However, due to its widespread …

[HTML][HTML] Liver injury induced by paracetamol and challenges associated with intentional and unintentional use

L Rotundo, N Pyrsopoulos - World journal of hepatology, 2020 - ncbi.nlm.nih.gov
Drug induced liver injury (DILI) is a common cause of acute liver injury. Paracetamol, also
known as acetaminophen, is a widely used anti-pyretic that has long been established to …

Drug hepatotoxicity

RA Nathwani, N Kaplowitz - Clinics in liver disease, 2006 - liver.theclinics.com
Drug-induced liver injury (DILI) is an important cause of liver disease with an incidence that
is on the rise given the ever-increasing availability of new standardized and …

[HTML][HTML] How to treat paracetamol overdose and when to do it

DJ Antoine, JW Dear - Expert review of clinical pharmacology, 2016 - Taylor & Francis
Paracetamol overdose remains a major medical problem and one of the major reasons for
acute liver failure in the Western world. It accounts for roughly 38,000 hospital admissions …

[HTML][HTML] Paracetamol-Induced Hepatotoxicity

N Mirza - Hepatotoxicity, 2022 - intechopen.com
Drug-induced hepatotoxicity is common in clinical settings, one of the commonly used drugs
leading to liver injury is paracetamol. It is a commonly used analgesic and antipyretic drug …

Clinical manifestations and treatment of drug-induced hepatotoxicity

CM Giordano, XB Zervos - Clinics in liver disease, 2013 - liver.theclinics.com
Greater than 1000 medications on the market have been associated with causing
hepatotoxicity. 1 Drug-induced liver injury (DILI) is implicated in most cases of acute liver …

Drug-induced liver injury

A Kumachev, PE Wu - Cmaj, 2021 - Can Med Assoc
Targeted therapy is appropriate for specific cases (eg, N-acetylcysteine for acetaminophen
toxicity5), but treatment is primarily to stop the offending drug. Glucocorticoids are not …