The generation and maintenance of B lymphocytes is controlled by biochemical signals
tramsitted by the B cell antigen receptor (BCR) complex. These signals are transduced by …

Mutations in Bruton's tyrosine kinase (Btk) result in the B‐cell immunodeficiencies X‐linked
agammaglobulinemia in humans and X‐linked immunodeficiency in mice. These diseases …

X-linked agammaglobulinemia (XLA) is an inherited human immunodeficiency disease,
characterized by an arrest in B-cell development, which results in a dramatic decrease in …

Mutations in the gene encoding Bruton's tyrosine kinase (btk) cause the B cell deficiency
diseases X-linked agammaglobulinemia (XLA) in humans and X-linked immunodeficiency …

Mutation of Bruton's tyrosine kinase (Btk) causes human X-linked agammaglobulinemia and
murine X-linked immunodeficiency syndrome (xid). Quantitative aspects of B lymphocyte …

X‐linked agammaglobulinemia (XLA) is one of the most frequent inherited
immunodeficiency diseases in man and is characterized by an almost complete arrest of B …

Mutations in Bruton's tyrosine kinase (Btk) result in the B cell immunodeficiencies XLA in
humans and Xid in mice. Both the maintenance of peripheral B cell numbers and their …

Btk is the protein affected in XLA, a disease identified as a B cell differentiation defect. Btk is
crucial for B cell differentiation and activation, but its role in other cells is not fully …

Bruton's tyrosine kinase (Btk) is a nonreceptor protein kinase that is defective in X-linked
agammaglobulinemia in humans and in X-linked immunodeficiency in mice. To study the …

Background Bruton's tyrosine kinase (Btk) is essential for B cell development and function.
Mutations of Btk elicit X-linked agammaglobulinemia in humans and X-linked …