Disease and accompanying inflammation are uncommon outcomes of viral infection in
humans. Clinical inflammation occurs if steady-state cell-intrinsic and leukocytic immunity to …

Much progress has been made in the identification of specific human gene variants that
contribute to enhanced susceptibility or resistance to viral diseases. Herein we review …

Viral infectious diseases signify an essential portion of global public health concern with
millions of deaths annually. Viruses produce disease directly by killing the host cells they …

Introduction Variation in an individual's response to environmental factors is likely to
influence susceptibility to complex human diseases. The genetic basis of such variation is …

The immediate response to viral infection relies on pattern-recognition receptors (PRRs),
most prominently the Toll-like receptors (TLRs) and the RNA helicases RIG-I and MDA5, as …

Great strides have been made in our understanding of the pathogenesis of autoimmune
diseases. Research has identified genetic associations, new functional subsets of effector …

Biologists, physicians and immunologists have contributed to the understanding of the
cellular participants and biological pathways involved in inflammation. Here, we provide a …

Although all multicellular organisms have germ line–encoded innate receptors to sense
pathogen-associated molecular patterns, vertebrates also evolved adaptive immunity based …

Does Inflammation Cut to the Heart of the Matter? | Science news careers commentary
Journals Science Science brought to you byGoogle Indexer Log in science science …

Introduction Many genetic variants associated with common disease susceptibility occur
close to immune-related genes in noncoding DNA, suggestive of a regulatory function. The …