This study investigated whether intermittent hypoxia (IH) induces airway
hyperresponsiveness (AHR) and associated with lung inflammation. Male Brown Norway …

Although chronic normobaric hypoxia (CH) alters lung function, its potential to induce
bronchial hyperreactivity (BHR) is still controversial. Thus the effects of CH on airway and …

The purpose of this study was to answer two questions concerning hyperoxia-induced
airway hyperresponsiveness: 1) What is the time course of the development of airway …

Chronic hypoxia has been shown to augment the production of antioxidants in rat lungs and
to reduce airway hyperreactivity in patients with asthma. This study investigated indirectly …

Rationale: Periodic occlusion of the upper airway in patients with obstructive sleep apnea
leads to chronic intermittent hypoxia, which increases the acute hypoxic ventilatory response …

Obstructive sleep apnea, similar to intermittent hypoxia (IH) during sleep, is associated with
laryngeal airway hyperreactivity (LAH). IH-induced laryngeal oxidative stress may contribute …

Ventilatory instability, reflected by enhanced acute hypoxic (AHVR) and hypercapnic
(AHCVR) ventilatory responses is a fundamental component of obstructive sleep apnoea …

Purpose Obesity increases the severity of asthma, and patients with severe asthma are often
complicated with obstructive sleep apnea syndrome (OSAS), a concomitant disease of …

We tested the hypothesis that prior exposure to alveolar hyperoxia prevents the hypoxia-
induced enhancement of bronchial reactivity, possibly via a cyclooxygenase-dependent …

Obstructive sleep apnea, manifested by intermittent hypoxia and excess production of
reactive oxygen species (ROS) in airways, is associated with hyperreactive airway diseases …