[HTML][HTML] Cholesterol and matrisome pathways dysregulated in astrocytes and microglia
The impact of apolipoprotein E ε4 (APOE4), the strongest genetic risk factor for Alzheimer's
disease (AD), on human brain cellular function remains unclear. Here, we investigated the …
disease (AD), on human brain cellular function remains unclear. Here, we investigated the …
APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia
The E4 allele of the apolipoprotein E gene (APOE) has been established as a genetic risk
factor for many diseases including cardiovascular diseases and Alzheimer's disease (AD) …
factor for many diseases including cardiovascular diseases and Alzheimer's disease (AD) …
[HTML][HTML] APOE4-carrying human astrocytes oversupply cholesterol to promote neuronal lipid raft expansion and Aβ generation
SI Lee, W Jeong, H Lim, S Cho, H Lee, Y Jang, J Cho… - Stem Cell Reports, 2021 - cell.com
The ε4 allele of APOE-encoding apolipoprotein (ApoE) is one of the strongest genetic risk
factors for Alzheimer's disease (AD). One of the overarching questions is whether and how …
factors for Alzheimer's disease (AD). One of the overarching questions is whether and how …
[HTML][HTML] APOE4 causes widespread molecular and cellular alterations associated with Alzheimer's disease phenotypes in human iPSC-derived brain cell types
Summary The apolipoprotein E4 (APOE4) variant is the single greatest genetic risk factor for
sporadic Alzheimer's disease (sAD). However, the cell-type-specific functions of APOE4 in …
sporadic Alzheimer's disease (sAD). However, the cell-type-specific functions of APOE4 in …
[HTML][HTML] APOE2, E3, and E4 differentially modulate cellular homeostasis, cholesterol metabolism, and inflammatory response in isogenic iPSC-derived astrocytes
SM de Leeuw, AWT Kirschner, K Lindner, R Rust… - Stem cell reports, 2022 - cell.com
Summary The apolipoprotein E4 (APOE4) variant is the strongest genetic risk factor for
Alzheimer disease (AD), while the APOE2 allele is protective. A major question is how …
Alzheimer disease (AD), while the APOE2 allele is protective. A major question is how …
[HTML][HTML] ApoE4-induced cholesterol dysregulation and its brain cell type-specific implications in the pathogenesis of Alzheimer's disease
W Jeong, H Lee, S Cho, J Seo - Molecules and cells, 2019 - Elsevier
Significant knowledge about the pathophysiology of Alzheimer's disease (AD) has been
gained in the last century; however, the understanding of its causes of onset remains limited …
gained in the last century; however, the understanding of its causes of onset remains limited …
[HTML][HTML] The Endosomal–Lysosomal Pathway Is Dysregulated by APOE4 Expression in Vivo
T Nuriel, KY Peng, A Ashok, AA Dillman… - Frontiers in …, 2017 - frontiersin.org
Possession of the ε4 allele of apolipoprotein E (APOE) is the major genetic risk factor for late-
onset Alzheimer's disease (AD). Although numerous hypotheses have been proposed, the …
onset Alzheimer's disease (AD). Although numerous hypotheses have been proposed, the …
[HTML][HTML] ApoE4 impairs neuron-astrocyte coupling of fatty acid metabolism
Alzheimer's disease (AD) risk gene ApoE4 perturbs brain lipid homeostasis and energy
transduction. However, the cell-type-specific mechanism of ApoE4 in modulating brain lipid …
transduction. However, the cell-type-specific mechanism of ApoE4 in modulating brain lipid …
[HTML][HTML] ApoE4-dependent lysosomal cholesterol accumulation impairs mitochondrial homeostasis and oxidative phosphorylation in human astrocytes
H Lee, S Cho, MJ Kim, YJ Park, E Cho, YS Jo, YS Kim… - Cell Reports, 2023 - cell.com
Recent developments in genome sequencing have expanded the knowledge of genetic
factors associated with late-onset Alzheimer's disease (AD). Among them, genetic variant ε4 …
factors associated with late-onset Alzheimer's disease (AD). Among them, genetic variant ε4 …
Peripheral apoE4 enhances Alzheimer's pathology and impairs cognition by compromising cerebrovascular function
The ε4 allele of the apolipoprotein E (APOE) gene, a genetic risk factor for Alzheimer's
disease, is abundantly expressed in both the brain and periphery. Here, we present …
disease, is abundantly expressed in both the brain and periphery. Here, we present …