Background: The transport of macromolecules between the nucleus and cytoplasm is an
energy-dependent process. Substrates are translocated across the nuclear envelope …

Macromolecules enter or leave the nucleus by using nuclear localization signals (NLS), or
nuclear export signals (NES), respectively. Different types of NLS and NES are recognized …

Nuclear transport is an energy-dependent process mediated by saturable receptors. Import
and export receptors are thought to recognize and bind to nuclear localization signals or …

Transport of macromolecules across the nuclear envelope is an active process that depends
on soluble factors including the GTPase Ran. Ran-GTP is predominantly located in the …

Transport of macromolecules into and out of the nucleus is generally effected by targeting
signals that are recognized by specific members of the importin/exportin transport receptor …

Molecules enter and exit the nucleus of eukaryotic cells through aqueous channels formed
in the nuclear envelope by nuclear pore complexes (NPC). Proteins entering or leaving the …

Importin β family transport receptors shuttle between the nucleus and the cytoplasm and
mediate transport of macromolecules through nuclear pore complexes (NPCs). The …

Background: Proteins generally enter or exit the nucleus as cargo of one of a small family of
import and export receptors. These receptors bear distant homology to importin β, a subunit …

Nuclear import and export signals on macromolecules mediate directional, receptor-driven
transport through the nuclear pore complex (NPC) by a process that is suggested to involve …

Soluble factors are required to mediate nuclear export of protein and RNA through the
nuclear pore complex (NPC). These soluble factors include receptors that bind directly to the …