RNA sequencing of transplant-stage idiopathic pulmonary fibrosis lung reveals unique pathway regulation
P Sivakumar, JR Thompson, R Ammar… - ERJ open …, 2019 - Eur Respiratory Soc
Idiopathic pulmonary fibrosis (IPF), the scarring of lung parenchyma resulting in the loss of
lung function, remains a fatal disease with a significant unmet medical need. Patients with …
lung function, remains a fatal disease with a significant unmet medical need. Patients with …
[HTML][HTML] Complex involvement of the extracellular matrix, immune effect, and lipid metabolism in the development of idiopathic pulmonary fibrosis
W Qian, S Xia, X Yang, J Yu, B Guo, Z Lin… - Frontiers in Molecular …, 2022 - frontiersin.org
Background and objective: Idiopathic pulmonary fibrosis (IPF) is an aggressive fibrotic
pulmonary disease with spatially and temporally heterogeneous alveolar lesions. There are …
pulmonary disease with spatially and temporally heterogeneous alveolar lesions. There are …
[HTML][HTML] Integrated plasma proteomics and lung transcriptomics reveal novel biomarkers in idiopathic pulmonary fibrosis
P Sivakumar, R Ammar, JR Thompson, Y Luo… - Respiratory …, 2021 - Springer
Background Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease with a significant
unmet medical need. Development of transformational therapies for IPF is challenging in …
unmet medical need. Development of transformational therapies for IPF is challenging in …
[HTML][HTML] Molecular phenotypes distinguish patients with relatively stable from progressive idiopathic pulmonary fibrosis (IPF)
K Boon, NW Bailey, J Yang, MP Steel, S Groshong… - PloS one, 2009 - journals.plos.org
Background Idiopathic pulmonary fibrosis (IPF) is a progressive, chronic interstitial lung
disease that is unresponsive to current therapy and often leads to death. However, the rate …
disease that is unresponsive to current therapy and often leads to death. However, the rate …
Cluster analysis of transcriptomic datasets to identify endotypes of idiopathic pulmonary fibrosis
Background Considerable clinical heterogeneity in idiopathic pulmonary fibrosis (IPF)
suggests the existence of multiple disease endotypes. Identifying these endotypes would …
suggests the existence of multiple disease endotypes. Identifying these endotypes would …
[HTML][HTML] Impact of transcriptomics on our understanding of pulmonary fibrosis
M Vukmirovic, N Kaminski - Frontiers in medicine, 2018 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF) is a lethal fibrotic lung disease characterized by aberrant
remodeling of the lung parenchyma with extensive changes to the phenotypes of all lung …
remodeling of the lung parenchyma with extensive changes to the phenotypes of all lung …
[HTML][HTML] Integrative multi-omics analysis reveals novel idiopathic pulmonary fibrosis endotypes associated with disease progression
Background Idiopathic pulmonary fibrosis (IPF) is characterized by the accumulation of
extracellular matrix in the pulmonary interstitium and progressive functional decline. We …
extracellular matrix in the pulmonary interstitium and progressive functional decline. We …
[HTML][HTML] A functional genomic model for predicting prognosis in idiopathic pulmonary fibrosis
Y Huang, SF Ma, R Vij, JM Oldham… - BMC pulmonary …, 2015 - Springer
Background The course of disease for patients with idiopathic pulmonary fibrosis (IPF) is
highly heterogeneous. Prognostic models rely on demographic and clinical characteristics …
highly heterogeneous. Prognostic models rely on demographic and clinical characteristics …
Evolving genomic approaches to idiopathic pulmonary fibrosis: moving beyond genes
DJ Kass, N Kaminski - Clinical and translational science, 2011 - Wiley Online Library
A little more than 10 years ago, the completed sequencing of the human genome boldly
promised to usher in an era of enhanced understanding and accelerated development of …
promised to usher in an era of enhanced understanding and accelerated development of …
[HTML][HTML] Detecting the molecular system signatures of idiopathic pulmonary fibrosis through integrated genomic analysis
I Gangwar, N Kumar Sharma, G Panzade, S Awasthi… - Scientific reports, 2017 - nature.com
Abstract Idiopathic Pulmonary Fibrosis (IPF) is an incurable progressive fibrotic disease of
the lungs. We currently lack a systematic understanding of IPF biology and a systems …
the lungs. We currently lack a systematic understanding of IPF biology and a systems …