IB4 afferent sprouting contributes to bladder dysfunction in spinal rats

NDT Zinck, JW Downie - Experimental neurology, 2008 - Elsevier
We investigated the role that nonpeptidergic isolectin-B4 (IB4) positive, primary afferent
sprouting plays in bladder dysfunction after spinal cord transection (SCT). Rats were …

The loss and progressive recovery of voiding after spinal cord interruption in rats is associated with simultaneous changes in autonomous contractile bladder activity

T Gevaert, G Owsianik, G Hutchings, L Van Leuven… - European urology, 2009 - Elsevier
BACKGROUND: Autonomous contractile activity (ACA) is a well-known phenomenon in
isolated bladders from different species and seems to be important in the physiology of both …

Plasticity in the injured spinal cord: can we use it to advantage to reestablish effective bladder voiding and continence?

NDT Zinck, JW Downie - Progress in Brain Research, 2006 - Elsevier
Micturition is coordinated at the level of the spinal cord and the brainstem. Spinal cord injury
therefore directly interrupts spinal neuronal pathways to the brainstem and results in bladder …

Effects of isolectin B4‐conjugated saporin, a targeting cytotoxin, on bladder overactivity induced by bladder irritation

J Nishiguchi, K Sasaki, S Seki… - European Journal of …, 2004 - Wiley Online Library
In order to clarify the functional role of the isolectin B4 (IB4)‐binding afferent pathway in the
micturition reflex, we investigated the effects on bladder activity of intrathecal application of …

Changes in micturition after spinal cord injury in conscious rats

M Yoshiyama, FM Nezu, O Yokoyama, WC de Groat… - Urology, 1999 - Elsevier
Objectives. To determine the feasibility of urodynamic monitoring of voiding function in
conscious, female spinal cord-injured (SCI) rats and to compare the voiding function in SCI …

Effect of urinary diversion on the recovery of micturition reflexes after spinal cord injury in the rat

MN Kruse, B Bennett, WC De Groat - The Journal of urology, 1994 - Elsevier
Patients with suprasacral spinal cord injury usually exhibit severe lower urinary tract
dysfunction, which is generally attributed to loss of supraspinal input to the spinal micturition …

Alterations in growth-associated protein (GAP-43) expression in lower urinary tract pathways following chronic spinal cord injury

MA Vizzard - Somatosensory & motor research, 1999 - Taylor & Francis
Alterations in the expression of growth-associated protein 43 (GAP-43) were examined in
lower urinary tract micturition reflex pathways 6 or 8 weeks following complete spinal cord …

Comparison of spinal cord contusion and transection: functional and histological changes in the rat urinary bladder

BN Breyer, TM Fandel, A Alwaal… - BJU …, 2017 - Wiley Online Library
Objective To compare the effect of complete transection (tSCI) and contusion spinal cord
injury (cSCI) on bladder function and bladder wall structure in rats. Materials and Methods A …

Suppression of detrusor-sphincter dysynergia by GABA-receptor activation in the lumbosacral spinal cord in spinal cord-injured rats

M Miyazato, K Sasatomi, S Hiragata… - American Journal …, 2008 - journals.physiology.org
We investigated the effects of intrathecal application of GABAA-or GABAB-receptor agonists
on detrusor-sphincter dyssynergia (DSD) in spinal cord transection (SCT) rats. Adult female …

GABA receptor activation in the lumbosacral spinal cord decreases detrusor overactivity in spinal cord injured rats

M Miyazato, K Sasatomi, S Hiragata… - The Journal of …, 2008 - auajournals.org
Purpose: We investigated the effects of intrathecal application of γ-aminobutyric acid A and
B receptor agonists on detrusor overactivity in spinal cord injured rats. Materials and …