Exosomes as CNS drug delivery tools and their applications

K Sun, X Zheng, H Jin, F Yu, W Zhao - Pharmaceutics, 2022 - mdpi.com
Central nervous system (CNS) diseases threaten the health of people all over the world.
However, due to the structural and functional particularities of the brain and spinal cord …

Exosomes based strategies for brain drug delivery

FU Rehman, Y Liu, M Zheng, B Shi - Biomaterials, 2023 - Elsevier
Exosome application has emerged as a promising nanotechnology discipline for various
diseases therapeutics and diagnoses. Owing to the natural properties of efficient drug …

Engineered exosomes: a promising drug delivery strategy for brain diseases

Y Jiang, F Wang, K Wang, Y Zhong… - Current Medicinal …, 2022 - ingentaconnect.com
Exosomes are a heterogeneous group of nano-sized natural membrane vesicles released
from various cells and exist in body fluids. Different from the previous understanding of the …

Recent progresses in exosome-based systems for targeted drug delivery to the brain

S Bashyal, C Thapa, S Lee - Journal of Controlled Release, 2022 - Elsevier
Despite the multiple ongoing and novel initiatives for developing brain-targeted drug
delivery systems, insurmountable obstacles remain. A perfect drug delivery device that can …

Harnessing exosomes for the development of brain drug delivery systems

M Zheng, M Huang, X Ma, H Chen… - Bioconjugate …, 2019 - ACS Publications
Brain drug delivery is one of the most important bottlenecks in the development of drugs for
the central nervous system. Cumulative evidence has emerged that extracellular vesicles …

Applications of extracellular vesicles in nervous system disorders: an overview of recent advances

SU Khan, MI Khan, MU Khan, NM Khan, S Bungau… - Bioengineering, 2022 - mdpi.com
Diseases affecting the brain and spinal cord fall under the umbrella term “central nervous
system disease”. Most medications used to treat or prevent chronic diseases of the central …

The therapeutic potential and clinical significance of exosomes as carriers of drug delivery system

T Li, X Li, G Han, M Liang, Z Yang, C Zhang, S Huang… - Pharmaceutics, 2022 - mdpi.com
Drug delivery system (DDS) realizes the drug delivery process through the drug carrier. As
an important part of DDS, the selection of the drug carrier material is extremely critical, which …

Exosome-Based Drug Delivery: Translation from Bench to Clinic

HB Koh, HJ Kim, SW Kang, TH Yoo - Pharmaceutics, 2023 - mdpi.com
Exosome-based drug delivery is emerging as a promising field with the potential to
revolutionize therapeutic interventions. Exosomes, which are small extracellular vesicles …

Exosome: a significant nano-scale drug delivery carrier

H Peng, W Ji, R Zhao, J Yang, Z Lu, Y Li… - Journal of Materials …, 2020 - pubs.rsc.org
In recent years, due to the limitations of the nature of therapeutic agents, many synthetic
nano-delivery systems have emerged to enhance the efficacy of drugs. Extracellular vesicles …

Recent advances in extracellular vesicles for therapeutic cargo delivery

HI Kim, J Park, Y Zhu, X Wang, Y Han… - Experimental & Molecular …, 2024 - nature.com
Exosomes, which are nanosized vesicles secreted by cells, are attracting increasing interest
in the field of biomedical research due to their unique properties, including biocompatibility …