Existence of escape mutant in HTLV-I tax during the development of adult T-cell leukemia

Y Furukawa, R Kubota, M Tara… - Blood, The Journal of …, 2001 - ashpublications.org
Although Tax protein is the main target of cytotoxic T lymphocyte (CTL) on human T-cell
lymphotropic virus type I (HTLV-I)–infected cells, and Tax peptide 11 through 19 binding to …

Naturally occurring variants of human T-cell leukemia virus type I Tax protein impair its recognition by cytotoxic T lymphocytes and the transactivation function of Tax

S Niewiesk, S Daenke, CE Parker, G Taylor… - Journal of …, 1995 - Am Soc Microbiol
There is a high degree of intraisolate sequence heterogeneity in the tax gene of human T-
cell leukemia virus type I (HTLV-I), although the sequence variation between patients is …

Human T-cell leukemia virus type-1 (HTLV-1) Tax is expressed at the same level in infected cells of HTLV-1-associated myelopathy or tropical spastic paraparesis …

Y Furukawa, M Osame, R Kubota, M Tara, M Yoshida - 1995 - ashpublications.org
Patients with human T-cell leukemia virus type-1 (HTLV-1)-associated myelopathy
(HAM/TSP) generally harbor a much greater population of HTLV-1-infected T cells in …

Abundant tax protein expression in CD4+ T cells infected with human T-cell lymphotropic virus type I (HTLV-I) is prevented by cytotoxic T lymphocytes

E Hanon, S Hall, GP Taylor, M Saito… - Blood, The Journal …, 2000 - ashpublications.org
The role of the cellular immune response in human T-cell leukemia virus type I (HTLV-I)
infection is not fully understood. A persistently activated cytotoxic T lymphocyte (CTL) …

Target epitope in the Tax protein of human T-cell leukemia virus type I recognized by class I major histocompatibility complex-restricted cytotoxic T cells

M Kannagi, H Shida, H Igarashi, K Kuruma… - Journal of …, 1992 - Am Soc Microbiol
A trans-acting regulatory gene product p40tax (Tax) of human T-cell leukemia virus type I
(HTLV-I) is one of the main target antigens recognized by cytotoxic T lymphocytes (CTL) …

[HTML][HTML] Life, death, and tax: role of HTLV-I oncoprotein in genetic instability and cellular transformation

KT Jeang, C Giam, F Majone, M Aboud - Journal of Biological Chemistry, 2004 - ASBMB
Human T-cell leukemia virus type I (HTLV-I) 1 causes adult T-cell leukemia (ATL)(1–3). The
virus is also associated with a neuropathy/myelopathy termed HTLV-associated myelopathy …

Human T-cell leukemia virus type I and adult T-cell leukemia

M Matsuoka - Oncogene, 2003 - nature.com
Human T-cell leukemia virus type I (HTLV-I) causes adult T-cell leukemia (ATL) in about 5%
of carriers after a long latent period. After its infection, HTLV-I promotes the clonal …

Mutational analysis of human T-cell leukemia virus type 2 Tax

TM Ross, AC Minella, ZY Fang, SM Pettiford… - Journal of …, 1997 - Am Soc Microbiol
A mutational analysis of human T-cell leukemia virus type 2 (HTLV-2) Tax (Tax-2) was
performed to identify regions within Tax-2 important for activation of promoters through the …

Circulating anti-Tax cytotoxic T lymphocytes from human T-cell leukemia virus type I-infected people, with and without tropical spastic paraparesis, recognize multiple …

CE Parker, S Nightingale, GP Taylor, J Weber… - Journal of …, 1994 - Am Soc Microbiol
CD8+ T cells were freshly isolated from a human T-cell leukemia virus type I (HTLV-I)-
infected patient with tropical spastic paraparesis. These cells, which were specific for HTLV-I …

Activation of interleukin-2 receptor alpha expression by extracellular HTLV-I Tax1 protein: a potential role in HTLV-I pathogenesis.

SJ Marriott, D Trinh, JN Brady - Oncogene, 1992 - europepmc.org
The Tax1 protein of human T cell leukemia/lymphoma virus type I (HTLV-I) has been shown
to stimulate the proliferation of human lymphocytes. Here we report that lymphocyte …