Liquid-liquid phase separation in biology: mechanisms, physiological functions and human diseases
Cells are compartmentalized by numerous membrane-enclosed organelles and
membraneless compartments to ensure that a wide variety of cellular activities occur in a …
membraneless compartments to ensure that a wide variety of cellular activities occur in a …
Membrane-associated phase separation: organization and function emerge from a two-dimensional milieu
JA Ditlev - Journal of Molecular Cell Biology, 2021 - academic.oup.com
Liquid–liquid phase separation (LLPS) of biomolecules has emerged as an important
mechanism that contributes to cellular organization. Phase-separated biomolecular …
mechanism that contributes to cellular organization. Phase-separated biomolecular …
Aberrant phase separation and cancer
K Taniue, N Akimitsu - The FEBS journal, 2022 - Wiley Online Library
Eukaryotic cells are intracellularly divided into numerous compartments or organelles, which
coordinate specific molecules and biological reactions. Membrane‐bound organelles are …
coordinate specific molecules and biological reactions. Membrane‐bound organelles are …
Formation of biological condensates via phase separation: Characteristics, analytical methods, and physiological implications
Liquid–liquid phase separation (LLPS) facilitates the formation of condensed biological
assemblies with well-delineated physical boundaries, but without lipid membrane barriers …
assemblies with well-delineated physical boundaries, but without lipid membrane barriers …
Phase separation in membrane biology: the interplay between membrane-bound organelles and membraneless condensates
YG Zhao, H Zhang - Developmental Cell, 2020 - cell.com
In eukaryotic cells, various membrane-bound organelles compartmentalize diverse cellular
activities in a spatially and temporally controlled manner. Numerous membraneless …
activities in a spatially and temporally controlled manner. Numerous membraneless …
Emerging roles of liquid–liquid phase separation in cancer: from protein aggregation to immune-associated signaling
J Lu, J Qian, Z Xu, S Yin, L Zhou, S Zheng… - Frontiers in cell and …, 2021 - frontiersin.org
Liquid–liquid Phase Separation (LLPS) of proteins and nucleic acids has emerged as a new
paradigm in the study of cellular activities. It drives the formation of liquid-like condensates …
paradigm in the study of cellular activities. It drives the formation of liquid-like condensates …
[HTML][HTML] Considerations and challenges in studying liquid-liquid phase separation and biomolecular condensates
Evidence is now mounting that liquid-liquid phase separation (LLPS) underlies the formation
of membraneless compartments in cells. This realization has motivated major efforts to …
of membraneless compartments in cells. This realization has motivated major efforts to …
Protocol for analyzing protein liquid–liquid phase separation
Numerous cellular functions occur in spatially and temporally confined regions. Recent
studies have shown that membrane-less organelles and compartments in the cell are …
studies have shown that membrane-less organelles and compartments in the cell are …
Liquid–liquid phase separation in human health and diseases
Emerging evidence suggests that liquid–liquid phase separation (LLPS) represents a vital
and ubiquitous phenomenon underlying the formation of membraneless organelles in …
and ubiquitous phenomenon underlying the formation of membraneless organelles in …
Programmable spatial organization of liquid-phase condensations
J Li, Z Xu, M Zhu, C Zhao, X Wang, H Chen, X Liu… - Chem, 2022 - cell.com
Liquid-liquid phase separation (LLPS) is recognized as an important means of intracellular
compartmentalization in living cells. However, the spontaneous formation of hierarchical …
compartmentalization in living cells. However, the spontaneous formation of hierarchical …