Colorectal cancer remains one of the most common cancers worldwide and, despite
improvements in treatment options for late-stage metastatic cancer, there are still questions …

Colon cancer (CC) has the highest incidence rate among gastrointestinal cancers and ranks
the third in mortality among all cancers, which contributes to the current CC burden and …

The use of adjuvant chemotherapy for stage II colon cancer remains controversial. The
accurate assessment of the risk factors associated with recurrence in patients with stage II …

For more than three decades, postoperative chemotherapy—initially fluoropyrimidines and
more recently combinations with oxaliplatin—has reduced the risk of tumor recurrence and …

Purpose Colorectal cancer (CRC) is a major health problem in the USA and worldwide. At
the time of initial presentation, approximately 26% of CRC patients will have stage II disease …

The treatment of stage II colon cancer is a controversial issue that has persisted for the past
decade. Clinicians must understand that accurate assessment of risk factors is the key to …

At the time of initial diagnosis, stage II colorectal cancer (CRC) accounts for approximately
25% of all CRC cases. In general, stage II disease is associated with a good prognosis with …

While many patients with early-stage colon cancer are cured with surgery alone, the
standard of care remains a uniform approach to adjuvant chemotherapy based primarily on …

Introduction Colorectal cancer (CRC) is the third most common and second most deadly
malignancy in the world with an estimated 1. 9 million cases and 0.9 million deaths in 2020 …

Understanding the biology of cancer is the key to understanding its behavior. Stage II colon
cancers represent a unique treatment challenge for medical oncologists because they …