Serotonin, or 5‐hydroxytryptamine, is a naturally‐occurring vasoactive substance found
primarily in the brain, enterochromaffin tissue, and blood platelets. It has diffuse …

Serotonin is a naturally occurring vasoactive substance that has diverse cardio-
physiological effects. These effects can be explained by the existence of serotonin receptor …

Aggregating platelets release serotonin, which induces contraction of most vascular smooth
muscle by activation of S2-serotoninergic receptors. Serotonin released in the circulation …

The major target for circulating serotonin (released from aggregating platelets) appears to
be the blood vessel wall (although little evidence is available), suggesting a role for the …

Serotonin released from aggregating platelets can reach sufficient concentrations to affect
local vascular function in a number of ways. The monoamine can cause contraction of blood …

The cardiovascular actions of serotonin and its antagonists are reviewed with a view to
clarifying whether serotonin has a role in blood pressure control through actions on the …

Serotonergic receptors have been identified in the blood vessels of the heart and in
myocardial tissue. We indirectly examined the potential significance of these receptors by …

Abstract Serotonin (5-hydroxytryptamine; also called 5-HT) modifies cardiovascular activity
by central as well as peripheral sites of action. When 5-HT is injected within the central …

Serotonin has several effects on vascular smooth muscle. In most vascular beds it causes
vasoconstriction, but under the proper conditions it can cause vasodilatation. The constrictor …

Serotonin induces constrictor responses on smooth muscle tissues from several vascular
regions mainly by its interaction with serotonin-S2 receptor sites. The individual sensitivity of …