[HTML][HTML] Treatment effect of bumetanide in children with autism spectrum disorder: a systematic review and meta-analysis
T Wang, L Shan, C Miao, Z Xu, F Jia - Frontiers in Psychiatry, 2021 - frontiersin.org
Background: The therapeutic effect of bumetanide on autism spectrum disorder (ASD)
seems to be controversial. To obtain better evidence on the efficacy of bumetanide, a …
seems to be controversial. To obtain better evidence on the efficacy of bumetanide, a …
Can bumetanide be a miraculous medicine for autism spectrum disorder: Meta-analysis evidence from randomized controlled trials
HL Xiao, H Zhu, JQ Jing, SJ Jia, SH Yu… - Research in Autism …, 2024 - Elsevier
Background The efficacy of bumetanide on autism spectrum disorders (ASD) has been
extensively studied, but the results remain inconclusive, necessitating a critical examination …
extensively studied, but the results remain inconclusive, necessitating a critical examination …
Bumetanide for autism spectrum disorder in children: a review of randomized controlled trials
BJ James, MA Gales, BJ Gales - Annals of …, 2019 - journals.sagepub.com
Objective: To evaluate clinical trials using bumetanide in autism spectrum disorder (ASD)
treatment. Data Sources: PubMed and Ovid MEDLINE (1946 to October 2018) were …
treatment. Data Sources: PubMed and Ovid MEDLINE (1946 to October 2018) were …
[HTML][HTML] Improved symptoms following bumetanide treatment in children aged 3− 6 years with autism spectrum disorder: a randomized, double-blind, placebo …
Y Dai, L Zhang, J Yu, X Zhou, H He, Y Ji, K Wang, X Du… - Science Bulletin, 2021 - Elsevier
With the current limited drug therapy for the core symptoms of autism spectrum disorder
(ASD), we herein report a randomized, double-blind, placebo-controlled trial to investigate …
(ASD), we herein report a randomized, double-blind, placebo-controlled trial to investigate …
[HTML][HTML] Bumetanide for core symptoms of autism spectrum disorder (BAMBI): a single center, double-blinded, participant-randomized, placebo-controlled, phase-2 …
JJ Sprengers, DM Van Andel, NPA Zuithoff… - Journal of the American …, 2021 - Elsevier
Objective Recent trials have indicated positive effects of bumetanide in autism spectrum
disorder (ASD). We tested efficacy of bumetanide on core symptom domains using a single …
disorder (ASD). We tested efficacy of bumetanide on core symptom domains using a single …
[HTML][HTML] Bumetanide therapeutic effect in children and adolescents with autism spectrum disorder: a review study
R Mollajani, MT Joghataei… - Basic and Clinical …, 2019 - ncbi.nlm.nih.gov
Methods: We searched all papers reported on pharmacokinetics, pharmacodynamics,
efficacy, and adverse effects of bumetanide on animal models and humans with ASD. The …
efficacy, and adverse effects of bumetanide on animal models and humans with ASD. The …
Bumetanide for autism: Open‐label trial in six children
E Fernell, P Gustafsson, C Gillberg - Acta paediatrica, 2021 - Wiley Online Library
Aim Bumetanide, a diuretic agent, that reduces intracellular chloride—thereby reinforcing
GABAergic inhibition—has been reported to improve core symptoms of autism in children …
GABAergic inhibition—has been reported to improve core symptoms of autism in children …
Bumetanide oral solution for the treatment of children and adolescents with autism spectrum disorder: Results from two randomized phase III studies
J Fuentes, M Parellada, C Georgoula… - Autism …, 2023 - Wiley Online Library
The efficacy and safety of bumetanide oral solution for the treatment of autism spectrum
disorder (ASD) in children and adolescents was evaluated in two international, multi‐center …
disorder (ASD) in children and adolescents was evaluated in two international, multi‐center …
[HTML][HTML] Effects of bumetanide on neurocognitive functioning in children with autism spectrum disorder: secondary analysis of a randomized placebo-controlled trial
DM van Andel, JJ Sprengers, M Königs… - Journal of Autism and …, 2024 - Springer
We present the secondary-analysis of neurocognitive tests in the 'Bumetanide in Autism
Medication and Biomarker'(BAMBI; EUDRA-CT-2014-001560-35) study, a randomized …
Medication and Biomarker'(BAMBI; EUDRA-CT-2014-001560-35) study, a randomized …
[HTML][HTML] Effects of bumetanide on neurobehavioral function in children and adolescents with autism spectrum disorders
E Lemonnier, N Villeneuve, S Sonie, S Serret… - Translational …, 2017 - nature.com
In animal models of autism spectrum disorder (ASD), the NKCC1 chloride-importer inhibitor
bumetanide restores physiological (Cl−) i levels, enhances GABAergic inhibition and …
bumetanide restores physiological (Cl−) i levels, enhances GABAergic inhibition and …