DHX15-independent roles for TFIP11 in U6 snRNA modification, U4/U6. U5 tri-snRNP assembly and pre-mRNA splicing fidelity
The U6 snRNA, the core catalytic component of the spliceosome, is extensively modified
post-transcriptionally, with 2'-O-methylation being most common. However, how U6 2'-O …
post-transcriptionally, with 2'-O-methylation being most common. However, how U6 2'-O …
A model for DHX15 mediated disassembly of A-complex spliceosomes
HM Maul-Newby, AN Amorello, T Sharma, JH Kim… - Rna, 2022 - rnajournal.cshlp.org
A critical step of pre-mRNA splicing is the recruitment of U2 snRNP to the branch point
sequence of an intron. U2 snRNP conformation changes extensively during branch helix …
sequence of an intron. U2 snRNP conformation changes extensively during branch helix …
TSSC4 is a component of U5 snRNP that promotes tri-snRNP formation
K Klimešová, J Vojáčková, N Radivojević… - Nature …, 2021 - nature.com
U5 snRNP is a complex particle essential for RNA splicing. U5 snRNPs undergo intricate
biogenesis that ensures that only a fully mature particle assembles into a splicing competent …
biogenesis that ensures that only a fully mature particle assembles into a splicing competent …
Spliceosome assembly in the absence of stable U4/U6 RNA pairing
JE Burke, SE Butcher, DA Brow - Rna, 2015 - rnajournal.cshlp.org
The cycle of spliceosome assembly, intron excision, and spliceosome disassembly involves
large-scale structural rearrangements of U6 snRNA that are functionally important. U6 enters …
large-scale structural rearrangements of U6 snRNA that are functionally important. U6 enters …
Cus2 enforces the first ATP-dependent step of splicing by binding to yeast SF3b1 through a UHM–ULM interaction
Stable recognition of the intron branchpoint (BP) by the U2 snRNP to form the pre-
spliceosome is the first ATP-dependent step of splicing. Genetic and biochemical data from …
spliceosome is the first ATP-dependent step of splicing. Genetic and biochemical data from …
Stem–loop 4 of U1 snRNA is essential for splicing and interacts with the U2 snRNP-specific SF3A1 protein during spliceosome assembly
The pairing of 5′ and 3′ splice sites across an intron is a critical step in spliceosome
formation and its regulation. Interactions that bring the two splice sites together during …
formation and its regulation. Interactions that bring the two splice sites together during …
Structure and assembly of the SF3a splicing factor complex of U2 snRNP
SF3a is an evolutionarily conserved heterotrimeric complex essential for pre‐mRNA
splicing. It functions in spliceosome assembly within the mature U2 snRNP (small nuclear …
splicing. It functions in spliceosome assembly within the mature U2 snRNP (small nuclear …
The conserved central domain of yeast U6 snRNA: importance of U2-U6 helix Ia in spliceosome assembly
DE Ryan, J Abelson - Rna, 2002 - cambridge.org
In the pre-mRNA processing machinery of eukaryotic cells, U6 snRNA is located at or near
the active site for pre-mRNA splicing catalysis, and U6 is involved in catalyzing the first …
the active site for pre-mRNA splicing catalysis, and U6 is involved in catalyzing the first …
Identification of a noncanonical RNA binding domain in the U2 snRNP protein SF3A1
W Martelly, B Fellows, K Senior, T Marlowe, S Sharma - Rna, 2019 - rnajournal.cshlp.org
During splicing of pre-mRNA, 5′ and 3′ splice sites are brought within proximity by
interactions between the pre-mRNA bound U1 and U2 snRNPs, followed by recruitment of …
interactions between the pre-mRNA bound U1 and U2 snRNPs, followed by recruitment of …
Synergistic roles for human U1 snRNA stem-loops in pre-mRNA splicing
W Martelly, B Fellows, P Kang, A Vashisht… - RNA biology, 2021 - Taylor & Francis
During spliceosome assembly, interactions that bring the 5′ and 3′ ends of an intron in
proximity are critical for the production of mature mRNA. Here, we report synergistic roles for …
proximity are critical for the production of mature mRNA. Here, we report synergistic roles for …