Macrophage heterogeneity and its impact on myocardial ischemia-reperfusion injury: an integrative review

S Xu, C Xu, J Xu, K Zhang, H Zhang - Journal of Inflammation …, 2023 - Taylor & Francis
The coronary reperfusion following acute myocardial infarction can paradoxically trigger
myocardial ischemia-reperfusion (IR) injury. This complex phenomenon involves the …

Macrophage-driven cardiac inflammation and healing: insights from homeostasis and myocardial infarction

W Zuo, R Sun, Z Ji, G Ma - Cellular & Molecular Biology Letters, 2023 - Springer
Early and prompt reperfusion therapy has markedly improved the survival rates among
patients enduring myocardial infarction (MI). Nonetheless, the resulting adverse remodeling …

Inflammation and inflammatory cells in myocardial infarction and reperfusion injury: a double-edged sword

J Liu, H Wang, J Li - Clinical Medicine Insights: Cardiology, 2016 - journals.sagepub.com
Myocardial infarction (MI) is the most common cause of cardiac injury, and subsequent
reperfusion further enhances the activation of innate and adaptive immune responses and …

Ischemia and reperfusion related myocardial inflammation: A network of cells and mediators targeting the cardiomyocyte

S Rohrbach, C Troidl, C Hamm, R Schulz - IUBMB life, 2015 - Wiley Online Library
Occlusion of a coronary artery if maintained for longer period of time results in damage of the
cardiac tissue. However, restoration of blood flow to previously ischemic tissue can itself …

Crosstalk between macrophages and cardiac cells after myocardial infarction

Y Jian, X Zhou, W Shan, C Chen, W Ge, J Cui… - Cell Communication and …, 2023 - Springer
Cardiovascular diseases, such as myocardial infarction (MI), are a leading cause of death
worldwide. Acute MI (AMI) inflicts massive injury to the coronary microcirculation, causing …

New insights and novel therapeutic potentials for macrophages in myocardial infarction

Z Zhang, J Tang, X Cui, B Qin, J Zhang, L Zhang… - Inflammation, 2021 - Springer
Cardiovascular disease (CVD) has long been the leading cause of death worldwide, and
myocardial infarction (MI) accounts for the greatest proportion of CVD. Recent research has …

Recent advances in potential targets for myocardial ischemia reperfusion injury: Role of macrophages

Q Zhuang, M Li, D Hu, J Li - Molecular Immunology, 2024 - Elsevier
Myocardial ischemia-reperfusion injury (MIRI) is a complex process that occurs when blood
flow is restored after myocardium infarction (MI) with exacerbated tissue damage …

Modulators of macrophage polarization influence healing of the infarcted myocardium

EN Ter Horst, N Hakimzadeh, AM Van der Laan… - International Journal of …, 2015 - mdpi.com
To diminish heart failure development after acute myocardial infarction (AMI), several
preclinical studies have focused on influencing the inflammatory processes in the healing …

Post-ischemic myocardial inflammatory response: a complex and dynamic process susceptible to immunomodulatory therapies

NJ Pluijmert, DE Atsma, PHA Quax - Frontiers in Cardiovascular …, 2021 - frontiersin.org
Following acute occlusion of a coronary artery causing myocardial ischemia and
implementing first-line treatment involving rapid reperfusion, a dynamic and balanced …

The role of macrophages in the infarcted myocardium: orchestrators of ECM remodeling

SA O'Rourke, A Dunne, MG Monaghan - Frontiers in cardiovascular …, 2019 - frontiersin.org
Myocardial infarction is the most common form of acute cardiac injury attributing to heart
failure. While there have been significant advances in current therapies, mortality and …