Severe traumatic events such as burns, and cancer therapy, often involve a significant loss
of tissue, requiring surgical reconstruction by means of autologous muscle flaps. The scant …

Tissue-engineered skeletal muscle can serve as a physiological model of natural muscle
and a potential therapeutic vehicle for rapid repair of severe muscle loss and injury. Here …

Insufficient vascularization during tissue repair is often associated with poor clinical
outcomes. This is a concern especially when patients have critical‐sized injuries, where the …

The size of in vitro engineered skeletal muscle tissue is limited due to the lack of a vascular
network in vitro. In this article, we report tissue-engineered skeletal muscle consisting of …

Musculoskeletal disorders are a major cause of disability and effective treatments are
currently lacking. Tissue engineering affords the possibility of new therapies utilizing cells …

Large soft tissue defects involve significant tissue loss, requiring surgical reconstruction.
Autologous flaps are occasionally scant, demand prolonged transfer surgery, and induce …

Traumatic skeletal muscle injuries cause irreversible tissue damage and impaired
revascularization. Engineered muscle is promising for enhancing tissue revascularization …

Tissue Engineering of skeletal muscle tissue still remains a major challenge. Every neo‐
tissue construct of clinically relevant dimensions is highly dependent on an intrinsic …

Regenerative efforts typically focus on the delivery of single factors, but it is likely that
multiple factors regulating distinct aspects of the regenerative process (eg, vascularization …

One of the major obstacles in engineering thick, complex tissues such as muscle is the need
to vascularize the tissue in vitro. Vascularization in vitro could maintain cell viability during …