The goal of this thesis is to describe the pharmacological approaches for modulation and
regulation of the p53 signaling pathway. The thesis provides general information about …

A common step in human cancer is the inactivation of the p53 tumor suppressor pathway.
This occurs either by mutations in the coding region of the p53 gene itself, or equally …

Abstract p53, a homo-tetrameric protein found in mammalian cells, derives its name from the
fact that it settles at around 53KDa position in SDS-PAGE, due to a “kink” in its structure. In …

In the last two decades since the first identification of p53 as a host protein that is bound by
the large T antigen of SV40 virus [1, 2], the investigation of the p53 gene has become a …

1. SUMMARY p53 is a key component of a stress-induced signalling pathway that is central
to tumour suppression. Various gene products in this p53 pathway are mutated in human …

Abstract p53 is one of the most frequently mutated genes in human cancer, and loss of p53
function after mutation contributes to the development of many of the major malignancies …

The p53 tumor suppressor gene plays an important role in preventing cancer development,
by arresting or killing potential tumor cells. Mutations within the p53 gene, leading to the loss …

While the tumor suppressor functions of p53 have long been recognized, the contribution of
p53 to numerous other aspects of disease and normal life is only now being appreciated …

In the 25 years since its first description the p53 protein has been shown to play a key role in
both tumour suppression and aging. New discoveries about the function and control of p53 …

The p53 protein is a transcription factor known as the" guardian of the genome" because of
its critical function in preserving genomic integrity. The TP53 gene is mutated in …