This year marks the 25th anniversary of the first Annual Review of Immunology article to
describe features of the T cell antigen receptor (TCR). In celebration of this anniversary, we …

The adaptive phase of the immune response begins with engagement on CD4+ helper T
cells of the T cell antigen receptor (TCR) 1 by its ligand, a small foreign peptide bound to a …

T cell development, differentiation, and maintenance are orchestrated by 2 key signaling
axes: the antigen-specific TCR and cytokine-mediated signals. The TCR signals the …

T cell activation requires extracellular stimulatory signals that are mainly mediated by T cell
receptor (TCR) complexes. The TCR recognizes antigens on major histocompatibility …

T cells use the αβ TCR to bind peptides presented by MHC proteins (pMHC) on APCs.
Formation of a TCR–pMHC complex initiates T cell signaling via a poorly understood …

The remarkable T cell receptor (TCR) performs essential functions in the initiation of
intracellular signals required for T cell development, repertoire selection and effector …

Sensitivity, specificity, and context discrimination are three key properties of T cell antigen
recognition. T lymphocytes recognize antigen as peptides bound to major histocompatibility …

“How does T cell receptor signaling begin?” Answering this question requires an
understanding of how the parts of the molecular machinery that mediates this process fit and …

TCR ligands are complexes of peptides and MHC proteins on the surfaces of APCs. Some of
these ligands cause T cell proliferation (agonists), while others block it (antagonists). We …

The initiation of T cell antigen receptor signaling is a key step that can result in T cell
activation and the orchestration of an adaptive immune response. Early events in T cell …