Thymic epithelial cells (TECs) are critical for the development and generation of functionally
competent T cells. Until now, the mechanism that regulates the survival of TECs is poorly …

Thymic epithelial cells (TECs) play important roles in T cell generation. Mechanisms that
control TEC development and function are still not well defined. The mammalian or …

The differentiation of mature medullary thymic epithelial cells (mTECs) is critical for the
induction of central immune tolerance. Although the critical effect of mechanistic target of …

Thymic epithelial cells (TECs) are critical for the establishment and maintenance of
appropriate microenvironment for the positive and negative selection of thymocytes and the …

T-cell differentiation is governed by interactions with thymic epithelial cells (TECs) and
defects in this process undermine immune function and tolerance. To uncover new …

Thymus is crucial for generation of a diverse repertoire of T cells essential for adaptive
immunity. Although thymic epithelial cells (TECs) are crucial for thymopoiesis and T cell …

The thymus is the primary lymphoid organ responsible for the generation and maturation of
T cells. Thymic epithelial cells (TECs) account for the majority of thymic stromal components …

Crosstalk between thymocytes and thymic epithelial cells is critical for T cell development
and the establishment of central tolerance. Medullary thymic epithelial cells (mTECs) play …

The mammalian target of rapamycin (mTOR) is a key regulator of cell growth and
metabolism. It associates with multiple proteins and forms two distinct signaling complexes …

Thymic epithelial cells (TECs) are the key components in thymic microenvironment for T
cells development. TECs, composed of cortical and medullary TECs, are derived from a …