The development and survival of thymic epithelial cells require TSC1-dependent negative regulation of mTORC1 activity
Z Liang, Q Zhang, Z Zhang, L Sun, X Dong… - The Journal of …, 2021 - journals.aai.org
Thymic epithelial cells (TECs) are critical for the development and generation of functionally
competent T cells. Until now, the mechanism that regulates the survival of TECs is poorly …
competent T cells. Until now, the mechanism that regulates the survival of TECs is poorly …
mTORC2 in thymic epithelial cells controls thymopoiesis and T cell development
HX Wang, JS Cheng, S Chu, YR Qiu… - The Journal of …, 2016 - journals.aai.org
Thymic epithelial cells (TECs) play important roles in T cell generation. Mechanisms that
control TEC development and function are still not well defined. The mammalian or …
control TEC development and function are still not well defined. The mammalian or …
mTORC2 negatively controls the maturation process of medullary thymic epithelial cells by inhibiting the LTβR/RANK‐NF‐κB axis
Z Liang, Q Zhang, X Dong, Z Zhang… - Journal of Cellular …, 2021 - Wiley Online Library
The differentiation of mature medullary thymic epithelial cells (mTECs) is critical for the
induction of central immune tolerance. Although the critical effect of mechanistic target of …
induction of central immune tolerance. Although the critical effect of mechanistic target of …
MTOR signaling is essential for the development of thymic epithelial cells and the induction of central immune tolerance
Thymic epithelial cells (TECs) are critical for the establishment and maintenance of
appropriate microenvironment for the positive and negative selection of thymocytes and the …
appropriate microenvironment for the positive and negative selection of thymocytes and the …
A critical epithelial survival axis regulated by MCL-1 maintains thymic function in mice
R Jain, JM Sheridan, A Policheni… - Blood, The Journal …, 2017 - ashpublications.org
T-cell differentiation is governed by interactions with thymic epithelial cells (TECs) and
defects in this process undermine immune function and tolerance. To uncover new …
defects in this process undermine immune function and tolerance. To uncover new …
[HTML][HTML] mTORC1 in thymic epithelial cells is critical for thymopoiesis, T-cell generation, and temporal control of γδT17 development and TCRγ/δ recombination
HX Wang, J Shin, S Wang, B Gorentla, X Lin, J Gao… - PLoS …, 2016 - journals.plos.org
Thymus is crucial for generation of a diverse repertoire of T cells essential for adaptive
immunity. Although thymic epithelial cells (TECs) are crucial for thymopoiesis and T cell …
immunity. Although thymic epithelial cells (TECs) are crucial for thymopoiesis and T cell …
[HTML][HTML] Thymic epithelial cells contribute to thymopoiesis and T cell development
HX Wang, W Pan, L Zheng, XP Zhong, L Tan… - Frontiers in …, 2020 - frontiersin.org
The thymus is the primary lymphoid organ responsible for the generation and maturation of
T cells. Thymic epithelial cells (TECs) account for the majority of thymic stromal components …
T cells. Thymic epithelial cells (TECs) account for the majority of thymic stromal components …
Medullary thymic epithelial cells, the indispensable player in central tolerance
YY Shi, MZ Zhu - Science China Life Sciences, 2013 - Springer
Crosstalk between thymocytes and thymic epithelial cells is critical for T cell development
and the establishment of central tolerance. Medullary thymic epithelial cells (mTECs) play …
and the establishment of central tolerance. Medullary thymic epithelial cells (mTECs) play …
Regulation of T‐cell survival and mitochondrial homeostasis by TSC1
TF O'Brien, BK Gorentla, D Xie… - European journal of …, 2011 - Wiley Online Library
The mammalian target of rapamycin (mTOR) is a key regulator of cell growth and
metabolism. It associates with multiple proteins and forms two distinct signaling complexes …
metabolism. It associates with multiple proteins and forms two distinct signaling complexes …
Thymic epithelial cell development and its dysfunction in human diseases
Thymic epithelial cells (TECs) are the key components in thymic microenvironment for T
cells development. TECs, composed of cortical and medullary TECs, are derived from a …
cells development. TECs, composed of cortical and medullary TECs, are derived from a …