Gallbladder cancer (GBC) is a rare but the most malignant type of biliary tract tumor. It is
usually diagnosed at an advanced stage and conventional treatments are unsatisfactory. As …

Background Chemotherapy is a standard cancer treatment which uses anti-cancer drugs to
destroy or slow the growth of cancer cells. However, chemotherapy has limited therapeutic …

Gallbladder cancer (GBC) is one of the most common and aggressive biliary tract diseases
with limited therapeutic strategies and poor prognosis. Various therapeutic agents have …

The application of combinational therapy makes up for the limitation of monotherapy and
achieves superior treatment against cancer. However, the combinational therapy remains …

Combination chemotherapy is a routine treatment for esophageal cancer, but some
shortcomings, such as drug toxicity and side effects, greatly limit the clinical application of …

The success of cancer chemotherapy is impeded by poor drug delivery efficiency due to the
existence of a series of pathophysiological barriers in the tumor. In this study, we reported a …

Abstract Bromodomain-Containing Protein 4 (BRD4) is a member of the BET family of
bromodomains, which participates in gene transcription process and is closely related to …

Tumor cells undergoing immunogenic cell death (ICD) have emerged as an in situ
therapeutic vaccine helping to activate a persistent anti-tumor response. Several …

Despite nanomedicine having shown great potential for reversing cancer cell resistance, the
suboptimal transport across multiple biological obstacles seriously impedes its reaching …

Multi-drug delivery focuses on different signaling pathways in cancer cells that have
synergistic anti-proliferative effects. In this study, we developed multi-prodrug nanocarriers …