Elevated levels of insulin-like growth factor-I (IGF-I) are associated with ovarian
carcinogenesis and progression. However, the molecular mechanisms by which IGF-I …

Both the insulin-like growth factor-I receptor (IGF-IR) and cyclooxygenase-2 (COX-2) are
frequently overexpressed in pancreatic cancer. We hypothesized that IGF-IR is directly …

Abstract Cyclooxygenase‐2 (COX‐2) expression contributes to tumor growth and invasion in
epithelial ovarian cancer (EOC). COX‐2 inhibitors exhibit important anticarcinogenic …

Nonsteroidal anti-inflammatory drugs reduce the risk of colon cancer and this effect is
mediated in part through inhibition of type 2 prostaglandin endoperoxide synthase/cyclo …

Constitutive overexpression of cyclooxygenase-2 (COX-2) occurs frequently in several
different malignancies, including lung, colon, breast, and prostate cancer. Clinical studies …

Cyclooxygenase-2 (COX-2) expression is a marker of poor prognosis in gastric cancer
patients, and its inhibition suppresses gastric tumorigenesis in experimental animal models …

We investigated the regulation of PG production in human endometrial stromal cells (ESC)
by IL-1β. We found that cyclooxygenase-2 (COX-2) mRNA and protein levels and PGE2 …

Abstract Cyclooxygenase 2 (COX-2) is often found overexpressed in cancer and is thought
to have a role in carcinogenic promotion and thus is a target for therapeutic intervention …

Cyclooxygenase (COX) 2 expression is regulated via the Ras signaling pathway, and
induction of mutated Ras rapidly increases COX-2 levels in intestinal epithelial cells. Protein …

Growing evidence shows that Interleukin (IL)-1β and Cyclooxygenase 2 (COX-2) play a
crucial role in the pathogenesis of inflammatory diseases and tumor growth, particularly in …