Astrocytic endfeet cover the entire cerebral vasculature and serve as exchange sites for
ions, metabolites and energy substrates from the blood to the brain. They maintain …

Astrocytes, members of the glial family, interact through the exchange of soluble factors or by
directly contacting neurons and other brain cells, such as microglia and endothelial cells …

Malignant gliomas are devastating tumours that frequently kill patients within 1 year of
diagnosis. The major obstacle to a cure is diffuse invasion, which enables tumours to …

Glioblastoma (GBM), a higher grade glial tumor, is highly aggressive, therapy resistant and
often shows poor patient prognosis due to frequent recurrence. These features of GBM are …

Glioblastoma is among the most common tumor of the central nervous system in adults.
Overall survival has not significantly improved over the last decade, even with optimizing …

Glioblastoma constitutes the most aggressive and deadly of brain tumors. As yet, both
conventional and molecular-based therapies have met with limited success in treatment of …

Vessel co-option is the movement of cancer cells towards and along the pre-existing
vasculature and is an alternative to angiogenesis to gain access to nutrients. Vessel co …

Treatment of adult brain tumors, in particular glioblastoma, remains a significant clinical
challenge, despite modest advances in surgical technique, radiation, and …

The blood-tumor barrier (BTB) is a major obstacle for drug delivery to malignant brain tumors
such as glioblastoma (GBM). Disrupting the BTB is therefore highly desirable but …

Glioma stem‐cells are associated with the brain vasculature. However, the way in which this
vascular niche regulates stem‐cell renewal and fate remains unclear. Here, we show that …