Flavonoids, coumarins and other polyphenolic compounds are powerful antioxidants both in
hydrophilic and lipophylic environments with diverse pharmacological properties including …

As polyphenolic compounds isolated from plants extracts, flavonoids have been applied to
various pharmaceutical uses in recent decades due to their anti-inflammatory, cancer …

Phagocytosis, a process involved in host defense, requires coordination of a variety of
signaling reactions. MT-II, a catalytically-inactive Lys49-PLA 2¸ and MT-III, an active Asp49 …

The biflavonoid morelloflavone has been reported as inhibitor of secretory PLA 2 s
(phospholipases A 2 from human synovial and bee venom sources); however, its capacity to …

Secretory phospholipases A2 (sPLA2s) play an important role in the generation of
inflammatory events in several human diseases. Secretory PLA2s obtained from snake …

In the present study, an acidic PLA2, designated Bl-PLA2, was isolated from Bothrops
leucurus snake venom through two chromatographic steps: ion-exchange on CM …

Flavonoids are potent anti-inflammatory compounds isolated from several plant extracts, and
have been used experimentally against inflammatory processes. In this work, a PLA2 …

We show that ethyl 2-oxo-2H-chromene-3-carboxylate (EOCC), a synthetic coumarin,
irreversibly inhibits phospholipase A2 (sPLA2) from Crotalus durissus ruruima venom …

Group IIA phospholipase A2 (PLA2) are major components in Viperidae/Crotalidae venom.
In the present study, a novel PLA2 named promutoxin with Arg at the site 49 has been …

This paper shows the results of quercitrin effects on the structure and biological activity of
secretory phospholipase (sPLA2) from Crotalus durissus terrificus, which is the main toxin …