Cellular theory of aging states that human aging is the result of cellular aging, in which an
increasing proportion of cells reach senescence. Senescence, from the Latin word senex …

Cellular senescence as the state of permanent inhibition of cell proliferation is a tumour-
suppressive mechanism. However, due to the associated secretory phenotype senescence …

Aging is the main risk factor for many degenerative diseases and declining health.
Senescent cells are part of the underlying mechanism for time-dependent tissue dysfunction …

Cellular senescence is a stress response, which can be evoked in all type of somatic cells
by different stimuli. Senescent cells accumulate in the body and participate in aging and …

The field of research on cellular senescence experienced a rapid expansion from being
primarily focused on in vitro aspects of aging to the vast territories of animal and clinical …

Cellular senescence is a permanent state of cell cycle arrest that occurs in proliferating cells
subjected to different stresses. Senescence is, therefore, a cellular defense mechanism that …

Cells can become senescent in response to stress. Senescence is a process characterised
by a stable proliferative arrest. Sometimes it can be beneficial—for example, it can suppress …

Human cells in culture have a limited proliferative capacity. After a period of vigorous
proliferation, the rate of cell division declines and a number of changes occur in the cells …

Cellular senescence is a stable cell cycle arrest that can be triggered in normal cells in
response to various intrinsic and extrinsic stimuli, as well as developmental signals …

Cell senescence is one of the major paradigms of aging research. It started with the
demonstration by L. Hayflick of the limited number of divisions by normal, nontransformed …