Cellular versatility depends on accurate trafficking of diverse proteins to their organellar
destinations. For the secretory pathway (followed by approximately 30% of all proteins), the …

Protein traffic is necessary to maintain homeostasis in all eukaryotic organisms. All newly
synthesized secretory proteins destined to the secretory and endolysosmal systems are …

Recent studies using GFP-tagged markers and time-lapse microscopy have allowed direct
visualisation of membrane traffic in the secretory pathway in living mammalian cells. This …

Protein transport from the endoplasmic reticulum (ER) to the Golgi apparatus is mediated by
coat complex II (COPII) vesicles. It has been believed that COPII vesicles containing cargo …

Protein transport between the ER and the Golgi in mammalian cells occurs via large
pleiomorphic carriers, and most current models suggest that these are formed by the fusion …

Protein traffic is of critical importance for normal cellular physiology. In eukaryotes, spherical
transport vesicles move proteins and lipids from one internal membrane-bound …

Metazoans require efficient and ordered secretion of extracellular matrix (ECM) to
coordinate cell and tissue function. Many ECM proteins are atypically large and their …

The Golgi apparatus comprises an enormous array of components that generate its unique
architecture and function within cells. Here, we use quantitative fluorescence imaging …

Vesicular transport from the endoplasmic reticulum (ER) to the Golgi complex constitutes the
initial step in protein secretion. COPII‐coated vesicles mediate the export of newly …

Secretory cargo is recognized, concentrated and trafficked from endoplasmic reticulum (ER)
exit sites (ERES) to the Golgi. Cargo export from the ER begins when a series of highly …