This Review discusses the potential usefulness of the worm Caenorhabditis elegans as a
model organism for chemists interested in studying living systems. C. elegans, a 1 mm long …

Covering: 2012 to 2023 The human population is aging. Thus, the greatest risk factor for
numerous diseases, such as diabetes, cancer and neurodegenerative disorders, is …

Among the first of my many mentors was my PhD supervisor, Colin Reese, who was
developing nonaqueous methods for oligonucleotide synthesis (see, for example, ref.[1]) …

Therapeutic drug development is a long, expensive, and complex process that usually takes
12–15 years. In the early phases of drug discovery, in particular, there is a growing need for …

The nematode Caenorhabditis elegans is a key model system for experimental research on
the genetic regulation of aging, and has paved the way towards many important discoveries …

This protocol describes a procedure for screening small molecules for bioactivity and a
genetic approach to target identification using the nematode Caenorhabditis elegans as a …

I never expected to spend most of my life studying worms. However, when the time came for
me to choose an area for my postdoctoral research, I was intrigued both with the problems of …

Caenorhabditis elegans lives in compost and decaying fruit, eats bacteria and is exposed to
pathogenic microbes. We show that C. elegans is able to modify diverse microbial small …

Molecular biology has driven a powerful reductionist, or “molecule-c-tric,” approach to
biological research in the last half of the 20th century. Red-tionism is the attempt to explain …

Drug discovery and drug target identification are two intimately linked facets of intervention
strategies aimed at effectively combating pathological conditions in humans. Simple model …