Constructing molecular complexity from simple precursors stands as a cornerstone in
contemporary organic synthesis. Systems harnessing easily accessible starting materials …

The selective activation of C–C bonds holds vast promise for catalysis. So far, research has
been primarily directed at rhodium and nickel under harsh reaction conditions. Herein, we …

Three that matter: Metal acetylides from alkyl propiolates allow C3 homologations with
transference of their versatile reactivity profile to products that can then react without further …

Derby, I'm reminded of the optimism and interest every year at the prospects of the winning
horse going on to take the Triple Crown. We gravitate to seeing patterns in threes, from book …

Multicomponent reactions allow for more bond-forming events per synthetic operation,
enabling more step-and time-economical conversion of simple starting materials to complex …

The design of synthetic routes by retrosynthetic logic is decisively influenced by the
transformations available. Transition‐metal‐catalyzed C− H activation has emerged as a …

Polyfunctional arenes are an important part of the chemical value chain. To improve the
efficiency of their synthesis, we have investigated a multicomponent approach built upon the …

We report on a three-component palladium-catalyzed coupling strategy for accessing a wide
range of 1, 4-diketones, which represent important precursors to heterocycles. Our method …

The direct cleavage of C (CO)− C single bonds, delivering otherwise inaccessible
compounds, is a significant challenge. Although the transition metal-catalyzed insertion of …

Single-atom catalysts (SACs) have generated excitement for their potential to downsize
metal particles to the atomic limit with engineerable local environments and improved …