Benzodiazepines form a class of drugs that are used to treat wide variety of conditions such
as anxiety, seizures, and insomnia. In general, benzodiazepines are lipophilic and poorly …

The cyclodextrin solubilization of three benzodiazepines, ie alprazolam, midazolam and
triazolam, was investigated. The cyclodextrin solubilization was enhanced through ring …

Inclusion complexes of 13 benzodiazepines with 3 cyclodextrins (α-, β-, γ-CyDs) in aqueous
solution and in the solid phase were studied by solubility methods, spectroscopy (UV, CD …

A parenteral formulation for the water-insoluble benzodiazepine diazepam was developed.
Different cyclodextrins (CDs) suitable for parenteral injection: hydroxypropyl-β-cyclodextrin …

Several attempts to increase diazepam solubility are in the literature. This study discusses
these different solubilization approaches. Specific reference is given to the rationale in the …

The poor aqueous solubility of carbamazepine was dramatically increased via complexation
with various chemically modified β-cyclodextrins and γ-cyclodextrins. A preparation of …

Benzodiazepines belong to a group of heterocyclic compounds that are widely used as
pharmaceuticals. They have a wide spectrum of pharmacological effects including anxiolytic …

Clonazepam (CLZ) is a benzodiazepine derivative, whose bioavailability, limited by its very
poor water-solubility, could be improved by cyclodextrin complexation. However, the choice …

Cyclodextrins are value‐adding functions excipients which have garnered significant
interest and are widely used in pharmaceutical and nutraceutical products. These materials …

The objectives of this research were to prepare and characterize inclusion complexes of
clonazepam with β-cyclodextrin and hydroxypropyl-β-cyclodextrin and to study the effect of …