Recent studies provide clues that astrocyte senescence is correlated with Parkinson's
disease (PD) progression, while little is known about the molecular basis for astrocyte …

Abstract Ataxia‐telangiectasia (A‐T) is a genetic disorder caused by the lack of functional
ATM kinase. A‐T is characterized by chronic inflammation, neurodegeneration and …

Senescence was recently linked to neurodegeneration and astrocytes are one of the major
cell types to turn senescent under neurodegenerative conditions. Senescent astrocytes were …

Cellular senescence, a state of irreversible cell-cycle arrest caused by a variety of cellular
stresses, is critically involved in age-related tissue dysfunction in various organs. However …

Neurodegeneration is a major age-related pathology. Cognitive decline is characteristic of
patients with Alzheimer's and related dementias and cancer patients after chemo-or radio …

Alzheimer's disease (AD) is the most common form of dementia characterized by
progressive memory loss and cognitive decline. Although neuroinflammation and oxidative …

Accumulation of β-amyloid and hyperphosphorylated tau with synapse damage and memory
deterioration are hallmark lesions of Alzheimer disease (AD), but the upstream causative …

Massive neuronal loss is a key pathological hallmark of Alzheimer's disease (AD). However,
the mechanisms are still unclear. Here we demonstrate that neuroinflammation, cell …

Aging is a major risk factor for many neurodegenerative disorders. A key feature of aging
biology that may underlie these diseases is cellular senescence. Senescent cells …

As the most abundant cell types in the brain, astrocytes form a tissue-wide signaling network
that is responsible for maintaining brain homeostasis and regulating various brain activities …