Bone tumors, especially those in osteosarcoma, usually occur in adolescents. The standard
clinical treatment includes chemotherapy, surgical therapy, and radiation therapy …

As a bone scaffold, meeting all basic requirements besides dealing with other bone-related
issues—bone cancer and accelerated regeneration—is not expected from traditional …

The postoperative tumor recurrence and chemotherapy resistance in clinical osteosarcoma
treatment have raised an imperative need to develop local implants for selectively killing …

Despite the significant improvement in the survival rate of cancer patients, the total cure of
bone cancer is still a knotty clinical challenge. Traditional surgical resectionof bone tumors is …

One of the most important ideas ever produced by the application of materials science to the
medical field is the notion of biomaterials. The nanostructured biomaterials play a crucial …

The treatment of bone defects remains one of the major challenges in modern clinical
practice. Nowadays, with the increased incidence of bone disease in an aging population …

Despite its intrinsic ability to regenerate form and function after injury, bone tissue can be
challenged by a multitude of pathological conditions. While innovative approaches have …

For treatment of bone tumor and regeneration of bone defects, the biomaterials should
possess the ability to kill tumor cells and regenerate bone defect simultaneously. To date …

Strategies for bone tissue regeneration have been continuously evolving for the last 25
years since the introduction of the “tissue engineering” concept. The convergence of the life …

A significant challenge in the current orthopedics is the development of suitable
osteobiologic materials that can replace the conventional allografts, autografts, and …