[HTML][HTML] Lifetime study in mice after acute low-dose ionizing radiation: a multifactorial study with special focus on cataract risk

C Dalke, F Neff, SK Bains, S Bright, D Lord… - Radiation and …, 2018 - Springer
Because of the increasing application of ionizing radiation in medicine, quantitative data on
effects of low-dose radiation are needed to optimize radiation protection, particularly with …

Radiation-induced lens opacity and cataractogenesis: A lifetime study using mice of varying genetic backgrounds

RA McCarron, SGR Barnard, G Babini… - Radiation …, 2022 - meridian.allenpress.com
Recent epidemiological findings and reanalysis of historical data suggest lens opacities
resulting from ionizing radiation exposures are likely induced at lower doses than previously …

Ionizing radiation sensitivity of the ocular lens and its dose rate dependence

N Hamada - International Journal of Radiation Biology, 2017 - Taylor & Francis
Abstract Purpose: In 2011, the International Commission on Radiological Protection reduced
the threshold for the lens effects of low linear energy transfer (LET) radiation. On one hand …

Sensitivity and latency of ionising radiation-induced cataract

EA Ainsbury, SGR Barnard - Experimental Eye Research, 2021 - Elsevier
When managed with appropriate radiation protection procedures, ionising radiation is of
great benefit to society. Opacification of the lens, and vision impairing cataract, have recently …

Early responses to low-dose ionizing radiation in cellular lens epithelial models

M Ahmadi, S Barnard, E Ainsbury… - Radiation …, 2022 - meridian.allenpress.com
Cataract is the leading cause of visual impairment which can result in blindness. Cataract
formation has been associated with radiation exposure; however, the mechanistic …

Ionizing radiation‐induced death in bovine lens epithelial cells: Mechanisms and influence of irradiation dose rate

Y Belkacémi, G Piel, P Rat, F Julia… - … journal of cancer, 2000 - Wiley Online Library
We recently reported, in a series of patients receiving total body irradiation before transplant,
an influence of dose rate (DR) on cataract formation. The aim of our present in vitro study …

Individual response of the ocular lens to ionizing radiation

SGR Barnard, N Hamada - International Journal of Radiation …, 2023 - Taylor & Francis
Purpose Cataract (opacification of the ocular lens) is a typical tissue reaction (deterministic
effect) following ionizing radiation exposure, for which prevention dose limits have been …

Radiation cataractogenesis: epidemiology and biology

EA Blakely, NJ Kleiman, K Neriishi… - Radiation …, 2010 - meridian.allenpress.com
An international workshop on Radiation Cataractogenesis, organized by Dr. Kazuo Neriishi,
was held March 9–10, 2009 at the Radiation Effects Research Foundation (RERF) in …

Ionizing radiation induced cataracts: Recent biological and mechanistic developments and perspectives for future research

EA Ainsbury, S Barnard, S Bright, C Dalke… - … Research/Reviews in …, 2016 - Elsevier
The lens of the eye has long been considered as a radiosensitive tissue, but recent research
has suggested that the radiosensitivity is even greater than previously thought. The 2012 …

Cataractogenesis following high-LET radiation exposure

N Hamada, T Sato - Mutation Research/Reviews in Mutation Research, 2016 - Elsevier
Biological effectiveness of ionizing radiation differs with its linear energy transfer (LET) such
that high-LET radiation is more effective for various biological endpoints than low-LET …