Safety of ustekinumab or vedolizumab in pregnant inflammatory bowel disease patients: a multicentre cohort study

P Wils, P Seksik, C Stefanescu… - Alimentary …, 2021 - Wiley Online Library
Background The prevalence of inflammatory bowel diseases (IBD) is high in women of
childbearing age. Achieving clinical remission from conception to delivery using current …

Safety of ustekinumab and vedolizumab during pregnancy—pregnancy, neonatal, and infant outcome: A prospective multicentre study

K Mitrova, B Pipek, M Bortlik, L Bouchner… - Journal of Crohn's …, 2022 - academic.oup.com
Abstract Background and Aims Evidence on the safety of newer biologics during pregnancy
is limited. We aimed to assess the safety of ustekinumab and vedolizumab treatment during …

Pregnancy outcomes in inflammatory bowel disease patients treated with vedolizumab, anti‐TNF or conventional therapy: results of the European CONCEIVE study

A Moens, CJ van der Woude… - Alimentary …, 2020 - Wiley Online Library
Background Women with inflammatory bowel diseases (IBD) often receive biologicals
during pregnancy to maintain disease remission. Data on outcome of vedolizumab‐exposed …

Ustekinumab during pregnancy in patients with inflammatory bowel disease: a prospective multicentre cohort study

I Avni‐Biron, T Mishael, E Zittan… - Alimentary …, 2022 - Wiley Online Library
Background Women with inflammatory bowel diseases (IBD) often receive biologics to
maintain remission during pregnancy. Aims To assess maternal and neonatal outcomes in …

Differences in the placental pharmacokinetics of vedolizumab and ustekinumab during pregnancy in women with inflammatory bowel disease: a prospective …

K Mitrova, B Pipek, M Bortlik… - Therapeutic …, 2021 - journals.sagepub.com
Background: Vedolizumab demonstrated different placental pharmacokinetics than other
immunoglobulin G1 antibodies, leading to lower drug levels in cord blood in contrast to …

[HTML][HTML] Biologics for inflammatory bowel disease and their safety in pregnancy: a systematic review and meta-analysis

OH Nielsen, JM Gubatan, CB Juhl, SE Streett… - Clinical …, 2022 - Elsevier
Background & Aims Biologics are used routinely in pregnant women with inflammatory
bowel disease (IBD), but large-scale data reporting adverse pregnancy outcomes among …

Outcome of pregnancies in female patients with inflammatory bowel diseases treated with vedolizumab

A Moens, K van Hoeve, E Humblet… - Journal of Crohn's …, 2019 - academic.oup.com
Abstract Background and Aims Vedolizumab is an IgG1 anti-α4β7 integrin antibody
approved for the treatment of inflammatory bowel diseases [IBD], but without clear safety …

Exposure to vedolizumab in IBD pregnant women appears of low risk for mother and neonate: a first prospective comparison study

ABG Shitrit, AB Ya'acov, DM Livovsky… - Official journal of the …, 2019 - journals.lww.com
OBJECTIVES: Despite encouraging data gathered in inflammatory bowel diseases (IBD)
patients, Vedolizumabs'(VDZ) safety profile in pregnancy is not established. DESIGN: Data …

Vedolizumab exposure in pregnancy: outcomes from clinical studies in inflammatory bowel disease

U Mahadevan, S Vermeire, K Lasch… - Alimentary …, 2017 - Wiley Online Library
Background Vedolizumab is a gut‐selective immunoglobulin G1 monoclonal antibody to
α4β7 integrin for the treatment of Crohn's disease (CD) and ulcerative colitis (UC) …

Ustekinumab levels in pregnant women with inflammatory bowel disease and infants exposed in utero

E Flanagan, R Prentice, EK Wright… - Alimentary …, 2022 - Wiley Online Library
Background Ustekinumab is increasingly used in pregnant women with inflammatory bowel
disease (IBD). Existing safety data are reassuring, but the stability of ustekinumab levels in …