Iron disorders of genetic origin are mainly composed of iron overload diseases, the most
frequent being HFE-related hemochromatosis. Hepcidin deficiency underlies iron overload …

Iron-loading disorders (haemochromatosis) represent an important class of human
diseases. Primary iron loading results from inherited disturbances in the mechanisms …

Hereditary hemochromatosis is a genetic disorder of iron overload. Over the past 15 years,
significant advances have been made in understanding the molecular pathogenesis of this …

Iron is biologically essential, but also potentially toxic; as such it is tightly controlled at cell
and systemic levels to prevent both deficiency and overload. Iron regulatory proteins post …

Non-HFE haemochromatosis is a negative definition applied to all those haemochromatosis
disorders that are unrelated to HFE mutations. Four genes are responsible for the distinct …

Dietary iron absorption and systemic iron traffic are tightly controlled by hepcidin, a liver-
derived peptide hormone. Hepcidin inhibits iron entry into plasma by binding to and …

Iron is an essential cofactor in a variety of cellular processes. Except for a few unusual
bacterial species, iron is indispensable for living organisms. However, free iron is toxic …

Iron metabolism in mammals requires a complex and tightly regulated molecular network.
The classical view of iron metabolism has been challenged over the past ten years by the …

There have been major basic advances in the field of iron metabolism in recent years. These
advances include the discoveries of the HFE-1 gene, a series of transmembrane iron …

Hereditary iron overload includes several disorders characterized by iron accumulation in
tissues, organs, or even single cells or subcellular compartments. They are determined by …