[HTML][HTML] Flavonoids activation of the transcription factor Nrf2 as a hypothesis approach for the prevention and modulation of SARS-CoV-2 infection severity
P Mendonca, KFA Soliman - Antioxidants, 2020 - mdpi.com
The Nrf2-Keap1-ARE pathway is the principal regulator of antioxidant and phase II
detoxification genes. Its activation increases the expression of antioxidant and cytoprotective …
detoxification genes. Its activation increases the expression of antioxidant and cytoprotective …
[HTML][HTML] Potential role of antioxidant and anti-inflammatory therapies to prevent severe SARS-Cov-2 complications
AM Fratta Pasini, C Stranieri, L Cominacini, C Mozzini - Antioxidants, 2021 - mdpi.com
The coronavirus disease 2019 (COVID-19) pandemic is caused by a novel severe acute
respiratory syndrome (SARS)-like coronavirus (SARS-CoV-2). Here, we review the …
respiratory syndrome (SARS)-like coronavirus (SARS-CoV-2). Here, we review the …
[HTML][HTML] Nrf2 Activator PB125® as a Potential Therapeutic Agent against COVID-19
JM McCord, BM Hybertson, A Cota-Gomez, KP Geraci… - Antioxidants, 2020 - mdpi.com
Nrf2 is a transcription factor that regulates cellular redox balance and the expression of a
wide array of genes involved in immunity and inflammation, including antiviral actions. Nrf2 …
wide array of genes involved in immunity and inflammation, including antiviral actions. Nrf2 …
[HTML][HTML] Anti-viral potential and modulation of Nrf2 by curcumin: pharmacological implications
Nuclear factor erythroid 2-related factor 2 (Nrf2) is an essential transcription factor that
maintains the cell's redox balance state and reduces inflammation in different adverse …
maintains the cell's redox balance state and reduces inflammation in different adverse …
[HTML][HTML] Transcription factor Nrf2 as a potential therapeutic target for prevention of cytokine storm in COVID-19 patients
RA Zinovkin, OA Grebenchikov - Biochemistry (Moscow), 2020 - Springer
Nrf2 is a key transcription factor responsible for antioxidant defense in many tissues and
cells, including alveolar epithelium, endothelium, and macrophages. Furthermore, Nrf2 …
cells, including alveolar epithelium, endothelium, and macrophages. Furthermore, Nrf2 …
SARS-CoV-2 inhibits NRF2-mediated antioxidant responses in airway epithelial cells and in the lung of a murine model of infection
Several viruses have been shown to modulate the transcription factor nuclear factor
erythroid 2-related factor 2 (NRF2), the master regulator of redox homeostasis. The severe …
erythroid 2-related factor 2 (NRF2), the master regulator of redox homeostasis. The severe …
[HTML][HTML] Flavonoids against the SARS-CoV-2 induced inflammatory storm
The disease severity of COVID-19, especially in the elderly and patients with co-morbidities,
is characterized by hypercytokinemia, an exaggerated immune response associated with an …
is characterized by hypercytokinemia, an exaggerated immune response associated with an …
Nrf2‐interacting nutrients and COVID‐19: time for research to develop adaptation strategies
J Bousquet, JP Cristol, W Czarlewski… - Clinical and …, 2020 - Wiley Online Library
There are large between‐and within‐country variations in COVID‐19 death rates. Some very
low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a …
low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a …
Roles of flavonoids against coronavirus infection
In terms of public health, the 21st century has been characterized by coronavirus
pandemics: in 2002-03 the virus SARS-CoV caused SARS; in 2012 MERS-CoV emerged …
pandemics: in 2002-03 the virus SARS-CoV caused SARS; in 2012 MERS-CoV emerged …
[HTML][HTML] Perspective: The potential effects of naringenin in COVID-19
RW Alberca, FME Teixeira, DR Beserra… - Frontiers in …, 2020 - frontiersin.org
Coronavirus disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome
Coronavirus-2 (SARS-CoV-2), was declared a pandemic by the World Health Organization …
Coronavirus-2 (SARS-CoV-2), was declared a pandemic by the World Health Organization …