Targeting brain Renin-Angiotensin System for the prevention and treatment of Alzheimer's disease: Past, present and future

F Gouveia, A Camins, M Ettcheto, J Bicker… - Ageing Research …, 2022 - Elsevier
Alzheimer's disease (AD) is a well-known neurodegenerative disease characterized by the
presence of two main hallmarks–Tau hyperphosphorylation and Aβ deposits …

Targeting renin–angiotensin system against Alzheimer's disease

AK Gebre, BM Altaye, TM Atey, KB Tuem… - Frontiers in …, 2018 - frontiersin.org
Renin Angiotensin System (RAS) is a hormonal system that regulates blood pressure and
fluid balance through a coordinated action of renal, cardiovascular, and central nervous …

Renin-angiotensin system and Alzheimer's disease pathophysiology: from the potential interactions to therapeutic perspectives

VT Ribeiro, LC de Souza… - Protein and Peptide …, 2020 - ingentaconnect.com
New roles of the Renin-Angiotensin System (RAS), apart from fluid homeostasis and Blood
Pressure (BP) regulation, are being progressively unveiled, since the discoveries of RAS …

Brain angiotensin II and angiotensin IV receptors as potential Alzheimer's disease therapeutic targets

J Royea, E Hamel - Geroscience, 2020 - Springer
Alzheimer's disease (AD) is a neurodegenerative disorder that is multifactorial in nature. Yet,
despite being the most common form of dementia in the elderly, AD's primary cause remains …

Current status of renin–aldosterone angiotensin system-targeting anti-hypertensive drugs as therapeutic options for Alzheimer's disease

EL Ashby, PG Kehoe - Expert opinion on investigational drugs, 2013 - Taylor & Francis
Introduction: Hypertension is a modifiable risk factor for Alzheimer's disease (AD) and other
dementias. Yet, despite this well-documented association, few of the current strategies to …

The brain RAS and Alzheimer's disease

JW Wright, JW Harding - Experimental neurology, 2010 - Elsevier
Alzheimer's disease (AD) has become a major world-wide health problem with ever rising
costs associated with the treatment and care of afflicted individuals. As life expectancy has …

Contributions by the brain renin-angiotensin system to memory, cognition, and Alzheimer's disease

JW Wright, JW Harding - Journal of Alzheimer's Disease, 2019 - content.iospress.com
Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive
neuron losses in memory-associated brain structures that rob patients of their dignity and …

The renin-angiotensin system and antihypertensive drugs in Alzheimer's disease: current standing of the angiotensin hypothesis?

PG Kehoe, PA Passmore - Journal of Alzheimer's Disease, 2012 - content.iospress.com
There is an urgent need to improve upon Alzheimer's disease (AD) treatments. Limitations of
existing drugs are that they target specific downstream neurochemical abnormalities while …

Evidence to consider angiotensin II receptor blockers for the treatment of early Alzheimer's disease

JM Saavedra - Cellular and molecular neurobiology, 2016 - Springer
Alzheimer's disease is the most frequent type of dementia and diagnosed late in the
progression of the illness when irreversible brain tissue loss has already occurred. For this …

Impact of renin–angiotensin system‐targeting antihypertensive drugs on treatment of Alzheimer's disease: a meta‐analysis

R Ye, Y Hu, A Yao, Y Yang, Y Shi… - … journal of clinical …, 2015 - Wiley Online Library
Objective The impacts of renin–angiotensin system (RAS)‐targeting antihypertensive drugs
on Alzheimer's disease (AD) remain controversial. We performed this meta‐analysis to …