Pyridine compounds with antimicrobial and antiviral activities

M Marinescu, CV Popa - International journal of molecular sciences, 2022 - mdpi.com
In the context of the new life-threatening COVID-19 pandemic caused by the SARS-CoV-2
virus, finding new antiviral and antimicrobial compounds is a priority in current research …

Synthesis, antimicrobial evaluation, molecular docking and theoretical calculations of novel pyrazolo [1, 5-a] pyrimidine derivatives

AM Fahim, AM Farag - Journal of Molecular Structure, 2020 - Elsevier
New fused heterocyclic compounds were synthesized starting from dimethyl terephthalate,
as a versatile precursor, via its reactions with the appropriate reagents. The structures of the …

Design, synthesis, molecular docking and in silico ADMET profile of pyrano [2, 3-d] pyrimidine derivatives as antimicrobial and anticancer agents

NEA Abd El-Sattar, K El‐Adl, MA El-Hashash… - Bioorganic …, 2021 - Elsevier
Abstract Pyrano [2, 3-d] pyrimidine derivatives were synthesized by treating cyclic
compounds containing active methylene group with aldehyde and malononitrile in butanol …

Synthesis, bioinformatics and biological evaluation of novel pyridine based on 8-hydroxyquinoline derivatives as antibacterial agents: DFT, molecular docking and …

M Rbaa, A Oubihi, H Hajji, B Tüzün, A Hichar… - Journal of Molecular …, 2021 - Elsevier
The present study aims to first explore the relationship between the chemical structure of the
organic compounds (pyridine based on 8-hydroxyquinoline) and the antibacterial activities …

Antiviral activities of pyridine fused and pyridine containing heterocycles, a review (from 2000 to 2020)

SR Alizadeh, MA Ebrahimzadeh - Mini Reviews in Medicinal …, 2021 - ingentaconnect.com
Heterocyclic compounds play a critical role in medicinal chemistry, and many available
drugs contain heterocyclic rings. A six-membered heterocyclic compound, pyridine, showed …

New pyrazolo-triazolo-pyrimidine derivatives as antibacterial agents: Design and synthesis, molecular docking and DFT studies

M Horchani, A Hajlaoui, AH Harrath, L Mansour… - Journal of Molecular …, 2020 - Elsevier
A new series of antibacterial pyrazolo-triazolo-pyrimidine derivatives 3a-3i were synthesized
in two steps starting from aminopyrazole 1 and characterized by 1 H NMR 13 C NMR and …

Synthesis and QSAR studies of pyrimido [4, 5-d] pyrimidine-2, 5-dione derivatives as potential antimicrobial agents

P Sharma, N Rane, VK Gurram - Bioorganic & medicinal chemistry letters, 2004 - Elsevier
A number of pyrimido [4, 5-d] pyrimidine-2, 5-dione derivatives were synthesized and
screened for antibacterial and antifungal activities. All the synthesized compounds showed …

Synthesis, characterization, and in vitro antibacterial activity of some new pyridinone and pyrazole derivatives with some in silico ADME and molecular modeling study

KE Saadon, NMH Taha, NA Mahmoud… - Journal of the Iranian …, 2022 - Springer
A new series of pyridine-2-one and pyrazole derivatives were designed and synthesized
based on cyanoacrylamide derivatives containing 2, 4-dichlro aniline and 6-methyl 2-amino …

Synthesis, molecular docking and antimicrobial activity of new fused pyrimidine and pyridine derivatives

MAA Radwan, MA Alshubramy, M Abdel-Motaal… - Bioorganic …, 2020 - Elsevier
Synthesis of some new heterocyclic ring systems incorporated pyrimidine and pyridine
moieties starting from 1-(furan-2-yl)-3-(thiophen-2-yl) chalcone was achieved. The structure …

Synthesis, antimycobacterial screening and ligand-based molecular docking studies on novel pyrrole derivatives bearing pyrazoline, isoxazole and phenyl thiourea …

SD Joshi, SR Dixit, MN Kirankumar… - European journal of …, 2016 - Elsevier
We report here the synthesis, antibacterial and antitubercular evaluation of 61 novel pyrrolyl
derivatives bearing pyrazoline, isoxazole and phenyl thiourea moieties. Molecular docking …