The role of CENP-B and α-satellite DNA: de novo assembly and epigenetic maintenance of human centromeres

H Masumoto, M Nakano, J Ohzeki - Chromosome research, 2004 - Springer
The centromere is an essential functional domain responsible for the correct inheritance of
eukaryotic chromosomes during cell division. Eukaryotic centromeres include the highly …

[HTML][HTML] CENP-B controls centromere formation depending on the chromatin context

T Okada, J Ohzeki, M Nakano, K Yoda, WR Brinkley… - Cell, 2007 - cell.com
The centromere is a chromatin region that serves as the spindle attachment point and directs
accurate inheritance of eukaryotic chromosomes during cell divisions. However, the …

Genetic and epigenetic regulation of centromeres: a look at HAC formation

J Ohzeki, V Larionov, WC Earnshaw… - Chromosome Research, 2015 - Springer
The centromere is a specialized chromosomal locus required for accurate chromosome
segregation. A specific histone H3 variant, CENP-A, assembles at centromeres. CENP-A is …

DNA sequences in centromere formation and function

M Dumont, D Fachinetti - Centromeres and Kinetochores: Discovering the …, 2017 - Springer
Faithful chromosome segregation during cell division depends on the centromere, a
complex DNA/protein structure that links chromosomes to spindle microtubules. This …

[HTML][HTML] DNA sequence-specific binding of CENP-B enhances the fidelity of human centromere function

D Fachinetti, JS Han, MA McMahon, P Ly, A Abdullah… - Developmental cell, 2015 - cell.com
Human centromeres are specified by a stably inherited epigenetic mark that maintains
centromere position and function through a two-step mechanism relying on self-templating …

Centromeric chromatin: what makes it unique?

S Henikoff, Y Dalal - Current opinion in genetics & development, 2005 - Elsevier
Centromeres represent the final frontier of eukaryotic genomes. Although they are defining
features of chromosomes—the points at which spindle microtubules attach—the …

Molecular underpinnings of centromere identity and maintenance

N Sekulic, BE Black - Trends in biochemical sciences, 2012 - cell.com
Centromeres direct faithful chromosome inheritance at cell division but are not defined by a
conserved DNA sequence. Instead, a specialized form of chromatin containing the histone …

Epigenetic regulation of centromere function

CYY Wong, BCH Lee, KWY Yuen - Cellular and Molecular Life Sciences, 2020 - Springer
The centromere is a specialized region on the chromosome that directs equal chromosome
segregation. Centromeres are usually not defined by DNA sequences alone. How …

Epigenomics of centromere assembly and function

KM Stimpson, BA Sullivan - Current opinion in cell biology, 2010 - Elsevier
The centromere is a complex chromosomal locus where the kinetochore is formed and
microtubules attach during cell division. Centromere identity involves both genomic and …

CENP-B box is required for de novo centromere chromatin assembly on human alphoid DNA

J Ohzeki, M Nakano, T Okada… - The Journal of cell biology, 2002 - rupress.org
Centromere protein (CENP) B boxes, recognition sequences of CENP-B, appear at regular
intervals in human centromeric α-satellite DNA (alphoid DNA). In this study, to determine …