Fungi, which can cause serious infections, results in more than 1.35 million deaths annually
throughout the world. Azole antifungal drugs which could inhibit the enzyme lanosterol 14α …

The incidence of invasive bacterial infections has increased remarkably over the past two
decades, which was mainly attributed to the increasing emergence of drug-resistant bacteria …

In this letter, we report our efforts to design, synthesize and evaluate biological activities of a
series of novel hybridized compounds containing 1-tetrazole and 4-pyridinyl-1, 2, 4-triazole …

Tetrazole, a bioisostere of the carboxylic acid group, can replace the carboxyl group in drugs
to increase the lipophilicity, bioavailability and reduce side effects. Tetrazole derivatives …

In an effort to find potent antifungal agents, a variety of triazole derivatives with a 5-
substituted tetrazole structure 6, 7, 12 and 14 were prepared and evaluated for antifungal …

The azole pharmacophore is still considered a viable lead structure for the synthesis of more
efficacious and broad spectrum antimicrobial agents. Potential antibacterial and antifungal …

In an effort to develop novel azole antifungals with potent activity and high selectivity, a
series of (2R, 3R)-3-((3-substitutied-phenyl-isoxazol-5-yl) methoxy)-2-(2, 4-difluorophenyl)-1 …

Cancer is one of the main causes of death throughout the world. The anticancer agents are
indispensable for the treatment of various cancers, but most of them currently on the market …

Today's research is focused on developing new safe drugs of clinical importance. Nitrogen-
containing heterocycles are abundant in the common of therapeutic scaffolds. Triazoles are …

Over the past decades, a tremendous rise in invasive fungal infection diseases attributed to
the yeast Candida albicans in immunocompromised individuals poses a seriously …