Bioequivalence and in vitro antimicrobial activity between generic and brand-name levofloxacin

HY Sun, HW Liao, MH Sheng, HM Tai, CH Kuo… - … and Infectious Disease, 2016 - Elsevier
Generic agents play a crucial role in reducing the cost of medical care in many countries.
However, the therapeutic equivalence remains a great concern. Our study aims to assess …

Comparative bioavailability of two formulations of levofloxacin and effect of sex on bioequivalence analysis

S Almeida, A Filipe, A Almeida, H Wong… - …, 2005 - thieme-connect.com
Bioequivalence of levofloxacin (CAS 100986-85-4) 500 mg tablets was assessed in a single
dose, open, randomised, crossover trial, with a minimum washout period of 7 days. Serum …

Bioequivalence study of levofloxacin tablets in healthy Indian volunteers using HPLC

A Das, J Mukherjee, G Dey, AK Sarkar… - …, 2011 - thieme-connect.com
An improved HPLC method was developed and validated for the determination of
concentration of levofloxacin (CAS 100986-85-4) in human plasma. This paper is an attempt …

[HTML][HTML] Levofloxacin: Insights into antibiotic resistance and product quality

E Izadi, G Afshan, RP Patel, VM Rao, KB Liew… - Frontiers in …, 2019 - frontiersin.org
Counterfeit and substandard medicines are recognized as one of serious threats to public
health. The product quality of antibacterial medicine will compromise patients' recovery and …

Physicochemical and bioequivalence studies on some brands of levofloxacin tablets registered in Nigeria.

CP Azubuike, S Oluyase - 2014 - ir.unilag.edu.ng
This study was aimed at comparing the physicochemical and bioavailability profiles of some
brands of Levofloxacin 500mg tablets that are registered in Nigeria by her regulatory …

Comparison of pharmacokinetics and stability of generics of cefepime, linezolid and piperacillin/tazobactam with their respective originator drugs: an intravenous …

F Bergmann, B Wulkersdorfer… - Journal of …, 2022 - academic.oup.com
Objectives The efficacy and quality of generic antibacterial drug formulations are often
questioned by both healthcare specialists and patients. Therefore, the present study …

A rapid and simple high‐performance liquid chromatography method for the determination of human plasma levofloxacin concentration and its application to …

ZL Zhou, M Yang, XY Yu, HY Peng… - Biomedical …, 2007 - Wiley Online Library
A high‐performance liquid chromatography method with fluorescence detection (HPLC‐
FLD) for the determination of levofloxacin in human plasma is described. Neutralized with …

[PDF][PDF] Therapeutic Equivalence Evaluated Through In Vitro Studies of Multi-Source Drugs: A Moxifloxacin Case Study in Lima, Peru

V Chumpitaz-Cerrate, L Moreno-Exebio… - Dissolution …, 2022 - dissolutiontech.com
This study aimed to determine the therapeutic equivalence of four multi-source drugs
containing moxifloxacin (400 mg tablets) in vitro studies to establish their interchangeability …

[PDF][PDF] Quality assessment of some brands of levofloxacin 500mg tablets commercially available in Gwagwalada, Abuja

VD Onalo - Sch Acad J Pharm, 2021 - researchgate.net
Background: Levofloxacin, a third generation fluoroquinolone and the L-isomer of the
racemate ofloxacin with improved antimicrobial activities. It is mostly prescribed and utilized …

Bioavailability of two oral formulations of a single dose of levofloxacin 500 mg: an open-label, randomized, two-period crossover comparison in healthy Mexican …

JF Galan-Herrera, JL Poo, O Rosales-Sanchez… - Clinical …, 2009 - Elsevier
Background: Levofloxacin is a synthetic fluoroquinolone with a broad spectrum of
antibacterial activity. It is indicated for the treatment of respiratory, sinus, skin, and urinary …