Piezo proteins are mechanically activated ion channels, which are required for
mechanosensing functions in a variety of cell types. While we and others have previously …

The skeleton is a dynamic tissue continuously adapting to mechanical stimuli. Although
matrix‐embedded osteocytes are considered as the key mechanoresponsive bone cells, all …

Bones and articular cartilage are important load-bearing tissues. The fluid flow inside the
bone cells and cell interaction with the extracellular matrix serve as the mechanical cues for …

Mechanotransduction is a fundamental ability that allows living organisms to receive and
respond to physical signals from both the external and internal environments. The …

Mechanical loading, such as caused by exercise, stimulates bone formation by osteoblasts
and increases bone strength, but the mechanisms are poorly understood. Osteocytes reside …

Mechanical load of the skeleton system is essential for the development, growth, and
maintenance of bone. However, the molecular mechanism by which mechanical stimuli are …

Piezo1 and Piezo2 are recently discovered mechanosensory ion channels. Piezo channels
transduce mechanical stimulation into cellular signaling in a variety of tissues and organ …

Wolff's law and the Utah Paradigm of skeletal physiology state that bone architecture adapts
to mechanical loads. These models predict the existence of a mechanostat that links strain …

As we age, our bones undergo a process of loss, often accompanied by muscle weakness
and reduced physical activity. This is exacerbated by decreased responsiveness to …

Osteoarthritis (OA) is a painful and debilitating condition of synovial joints without any
disease-modifying therapies [AM Valdes, TD Spector, Nat. Rev. Rheumatol. 7, 23–32 …