[HTML][HTML] Proteasome inhibition mediates p53 reactivation and anti-cancer activity of 6-gingerol in cervical cancer cells

N Rastogi, S Duggal, SK Singh, K Porwal… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Human papilloma virus (HPV) expressing E6 and E7 oncoproteins, is known to inactivate
the tumor suppressor p53 through proteasomal degradation in cervical cancers. Therefore …

[HTML][HTML] Quercetin induces G2 phase arrest and apoptosis with the activation of p53 in an E6 expression‑independent manner in HPV‑positive human cervical cancer …

AF Clemente‑Soto, E Salas‑Vidal… - Molecular …, 2019 - spandidos-publications.com
Cervical cancer is the second most common cancer in women worldwide. Human
papillomavirus (HPV) infection appears to be a necessary factor in the development of …

6‐Gingerol mediates its anti tumor activities in human oral and cervical cancer cell lines through apoptosis and cell cycle arrest

V Kapoor, S Aggarwal, SN Das - Phytotherapy research, 2016 - Wiley Online Library
6‐Gingerol, a potent nutraceutical, has been shown to have antitumor activity in different
tumors, although its mechanism of action is not well understood. In this study, we evaluated …

[HTML][HTML] Potential antitumor effects of 6-gingerol in p53-dependent mitochondrial apoptosis and inhibition of tumor sphere formation in breast cancer cells

N Sp, DY Kang, JM Lee, SW Bae, KJ Jang - International journal of …, 2021 - mdpi.com
Hormone-specific anticancer drugs for breast cancer treatment can cause serious side
effects. Thus, treatment with natural compounds has been considered a better approach as …

The Cytotoxicity Mechanism of 6‐shogaol‐treated HeLa human cervical cancer cells revealed by label‐free shotgun proteomics and bioinformatics analysis

Q Liu, YB Peng, LW Qi, XL Cheng, XJ Xu… - Evidence‐Based …, 2012 - Wiley Online Library
Cervical cancer is one of the most common cancers among women in the world. 6‐Shogaol
is a natural compound isolated from the rhizome of ginger (Zingiber officinale). In this paper …

10-Gingerol, a phytochemical derivative from “tongling white ginger”, inhibits cervical cancer: insights into the molecular mechanism and inhibitory targets

F Zhang, K Thakur, F Hu, JG Zhang… - Journal of Agricultural …, 2017 - ACS Publications
With the aim of evaluating anticancerous activities of 10-gingerol (10-G) against HeLa cells,
it was purified and identified from “Tongling white ginger” by HSCCC, UPLC-TOF-MS/MS …

[HTML][HTML] The Inhibitory Effect of 6-Gingerol on Ubiquitin-Specific Peptidase 14 Enhances Autophagy-Dependent Ferroptosis and Anti-Tumor in vivo and in vitro

Y Tsai, C Xia, Z Sun - Frontiers in Pharmacology, 2020 - frontiersin.org
Lung cancer is the most common malignant tumor and is the leading cause of cancer-
related deaths worldwide. Extraction of bioactive substances from herbs is considered as an …

[HTML][HTML] 14-3-3 zeta is a molecular target in guggulsterone induced apoptosis in head and neck cancer cells

MA Macha, A Matta, SS Chauhan, KWM Siu, R Ralhan - BMC cancer, 2010 - Springer
Background The five-year survival rates for head and neck squamous cell carcinoma
(HNSCC) patients are less than 50%, and the prognosis has not improved, despite …

Assessment of anti-cancerous potential of 6-gingerol (Tongling White Ginger) and its synergy with drugs on human cervical adenocarcinoma cells

F Zhang, JG Zhang, J Qu, Q Zhang, C Prasad… - Food and chemical …, 2017 - Elsevier
The anti-cancerous activity of 6-gingerol extracted from Tongling White Ginger was
investigated. 6-Gingerol inhibited the growth of HeLa cells with IC50 (96.32 μM) and IC80 …

[HTML][HTML] The curcumin analogue 1, 5-bis (2-hydroxyphenyl)-1, 4-pentadiene-3-one induces apoptosis and downregulates E6 and E7 oncogene expression in HPV16 …

F Paulraj, F Abas, NH Lajis, I Othman, S Syed Hassan… - Molecules, 2015 - mdpi.com
In an effort to study curcumin analogues as an alternative to improve the therapeutic efficacy
of curcumin, we screened the cytotoxic potential of four diarylpentanoids using the HeLa and …