[HTML][HTML] Proteasome inhibition mediates p53 reactivation and anti-cancer activity of 6-gingerol in cervical cancer cells
Human papilloma virus (HPV) expressing E6 and E7 oncoproteins, is known to inactivate
the tumor suppressor p53 through proteasomal degradation in cervical cancers. Therefore …
the tumor suppressor p53 through proteasomal degradation in cervical cancers. Therefore …
[HTML][HTML] Quercetin induces G2 phase arrest and apoptosis with the activation of p53 in an E6 expression‑independent manner in HPV‑positive human cervical cancer …
AF Clemente‑Soto, E Salas‑Vidal… - Molecular …, 2019 - spandidos-publications.com
Cervical cancer is the second most common cancer in women worldwide. Human
papillomavirus (HPV) infection appears to be a necessary factor in the development of …
papillomavirus (HPV) infection appears to be a necessary factor in the development of …
6‐Gingerol mediates its anti tumor activities in human oral and cervical cancer cell lines through apoptosis and cell cycle arrest
V Kapoor, S Aggarwal, SN Das - Phytotherapy research, 2016 - Wiley Online Library
6‐Gingerol, a potent nutraceutical, has been shown to have antitumor activity in different
tumors, although its mechanism of action is not well understood. In this study, we evaluated …
tumors, although its mechanism of action is not well understood. In this study, we evaluated …
[HTML][HTML] Potential antitumor effects of 6-gingerol in p53-dependent mitochondrial apoptosis and inhibition of tumor sphere formation in breast cancer cells
Hormone-specific anticancer drugs for breast cancer treatment can cause serious side
effects. Thus, treatment with natural compounds has been considered a better approach as …
effects. Thus, treatment with natural compounds has been considered a better approach as …
The Cytotoxicity Mechanism of 6‐shogaol‐treated HeLa human cervical cancer cells revealed by label‐free shotgun proteomics and bioinformatics analysis
Cervical cancer is one of the most common cancers among women in the world. 6‐Shogaol
is a natural compound isolated from the rhizome of ginger (Zingiber officinale). In this paper …
is a natural compound isolated from the rhizome of ginger (Zingiber officinale). In this paper …
10-Gingerol, a phytochemical derivative from “tongling white ginger”, inhibits cervical cancer: insights into the molecular mechanism and inhibitory targets
F Zhang, K Thakur, F Hu, JG Zhang… - Journal of Agricultural …, 2017 - ACS Publications
With the aim of evaluating anticancerous activities of 10-gingerol (10-G) against HeLa cells,
it was purified and identified from “Tongling white ginger” by HSCCC, UPLC-TOF-MS/MS …
it was purified and identified from “Tongling white ginger” by HSCCC, UPLC-TOF-MS/MS …
[HTML][HTML] The Inhibitory Effect of 6-Gingerol on Ubiquitin-Specific Peptidase 14 Enhances Autophagy-Dependent Ferroptosis and Anti-Tumor in vivo and in vitro
Y Tsai, C Xia, Z Sun - Frontiers in Pharmacology, 2020 - frontiersin.org
Lung cancer is the most common malignant tumor and is the leading cause of cancer-
related deaths worldwide. Extraction of bioactive substances from herbs is considered as an …
related deaths worldwide. Extraction of bioactive substances from herbs is considered as an …
[HTML][HTML] 14-3-3 zeta is a molecular target in guggulsterone induced apoptosis in head and neck cancer cells
Background The five-year survival rates for head and neck squamous cell carcinoma
(HNSCC) patients are less than 50%, and the prognosis has not improved, despite …
(HNSCC) patients are less than 50%, and the prognosis has not improved, despite …
Assessment of anti-cancerous potential of 6-gingerol (Tongling White Ginger) and its synergy with drugs on human cervical adenocarcinoma cells
F Zhang, JG Zhang, J Qu, Q Zhang, C Prasad… - Food and chemical …, 2017 - Elsevier
The anti-cancerous activity of 6-gingerol extracted from Tongling White Ginger was
investigated. 6-Gingerol inhibited the growth of HeLa cells with IC50 (96.32 μM) and IC80 …
investigated. 6-Gingerol inhibited the growth of HeLa cells with IC50 (96.32 μM) and IC80 …
[HTML][HTML] The curcumin analogue 1, 5-bis (2-hydroxyphenyl)-1, 4-pentadiene-3-one induces apoptosis and downregulates E6 and E7 oncogene expression in HPV16 …
In an effort to study curcumin analogues as an alternative to improve the therapeutic efficacy
of curcumin, we screened the cytotoxic potential of four diarylpentanoids using the HeLa and …
of curcumin, we screened the cytotoxic potential of four diarylpentanoids using the HeLa and …
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- cancer cells cytotoxicity mechanism
- cancer cells oncogene expression
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- phase arrest activation of p53
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