Proteins are the functional output of genes. The proteome is defined as the expressed
protein and peptide complement of a cell, organ, or organism, including all isoforms and …

The novel discipline of proteomics has experienced a rapid growth in the recent past and
has a great potential for the future. Involving several fields, it offers various advantages: The …

Noninvasive diagnosis of kidney diseases and assessment of the prognosis are still
challenges in clinical nephrology. Definition of biomarkers on the basis of proteome …

Abstract Treatment effectiveness for kidney disease is limited by lack of accuracy, sensitivity,
specificity of diagnostic, prognostic, and therapeutic biomarkers. The gold standard test …

Biomarkers have the potential to greatly facilitate diagnosis and treatment of patients with
various forms of kidney disease. State-of-the-art mass spectrometry-based methods possess …

Proteomic biomarkers offer the hope of improving the management of patients with kidney
diseases by enabling more accurate and earlier detection of renal pathology than is …

ical proteomics. Applications of renal and urinary proteomics have the ultimate goals of
better understanding of renal (patho) physiology, identification of new therapeutic targets …

Many challenges exist with disease-state biomarker identification. These challenges include
sample heterogeneity, poorly designed sample sets, insufficient numbers of samples, as …

Proteome analysis has emerged as a new field of protein science offering the possibility of
achieving unbiased identification, quantification and functional assessment of all proteins …

Proteomics-based approaches are generating considerable data in clinical nephrology
covering almost all aspects of the discipline. Proteomic experiments commonly involve …