Tissue-resident macrophages play an important role in the local maintenance of
homeostasis and immune surveillance. In the central nervous system (CNS), brain …

Being immune privileged, the central nervous system (CNS) is constituted by unique
parenchymal and non-parenchymal tissue-resident macrophages, namely, microglia and …

Simple Summary In the central nervous system, immune cells can be broadly categorized as
parenchymal microglia or non-parenchymal border-associated macrophages. It has become …

Highlights•BAMs are phenotypically and ontogenically distinct from parenchymal
microglia.•BAMs are strategically placed to protect the border regions of the CNS.•Single …

CNS-resident macrophages—including parenchymal microglia and border-associated
macrophages (BAMs)—contribute to neuronal development and health, vascularization, and …

Tissue-resident macrophages play an important role in maintaining tissue homeostasis and
innate immune defense against invading microbial pathogens. Brain-resident macrophages …

CNS border-associated macrophages (BAMs) are a small population of specialised
macrophages localised in the choroid plexus, meningeal and perivascular spaces. Until …

Since the discovery of microglia 100 years ago, the functions of this glial cell population in
the central nervous system (CNS) have been widely investigated. Microglia were initially …

Mammalian brain border-associated macrophages (BAMs) are strategically positioned to
support vital properties and processes: for example, the composition of the brain's …

Brain macrophages include microglia in the parenchyma, border-associated macrophages
in the meningeal-choroid plexus-perivascular space, and monocyte-derived macrophages …