Estimating parameters such as pulmonary drug disposition and deposited dose, as well as
determining the influence of pulmonary pharmacokinetics (PK) on drug efficacy and safety …

Over the past 20 years, the isolated perfused lung (IPL) technique has been developed for
the evaluation of pulmonary drug absorption and disposition. The procedure for establishing …

The ex vivo isolated perfused rat lung (IPL) model has been demonstrated to be a useful tool
during drug development for studying pulmonary drug absorption. This study aims to …

Systemic exposure of inhaled drugs is used to estimate the local lung exposure and assess
systemic side effects for drugs with local pharmacological targets. Predicting systemic …

Introduction: Inhaled drugs are important in the treatment of many lung pathologies, but to be
therapeutically effective they must reach unbound concentrations at their effect site in the …

During the last decades, the importance of modeling and simulation in clinical drug
development, with the goal to qualitatively and quantitatively assess and understand …

The assessment and prediction of lung absorption and disposition are an increasingly
essential preclinical task for successful discovery and product development of inhaled drugs …

Increasing affinity to lung tissue is an important strategy to achieve pulmonary retention and
to prolong the duration of effect in the lung. As the lung is a very heterogeneous organ …

Over the last decades, pharmacometric approaches became more widely applied to analyze
the pharmacokinetics (PK) of drugs, ranging from empirical to mechanistic physiologically …

The kinetic clarification of lung disposition for inhaled drugs in humans via pharmacokinetic
(PK) modeling aids in their development and regulation for systemic and local delivery, but …