[PDF][PDF] Cutaneous leishmaniasis induces a transmissible dysbiotic skin microbiota that promotes skin inflammation

C Gimblet, JS Meisel, MA Loesche, SD Cole… - Cell host & …, 2017 - cell.com
Skin microbiota can impact allergic and autoimmune responses, wound healing, and anti-
microbial defense. We investigated the role of skin microbiota in cutaneous leishmaniasis …

Microbiota instruct IL-17A-producing innate lymphoid cells to promote skin inflammation in cutaneous leishmaniasis

TP Singh, AM Carvalho, LA Sacramento… - PLoS …, 2021 - journals.plos.org
Innate lymphoid cells (ILCs) comprise a heterogeneous population of immune cells that
maintain barrier function and can initiate a protective or pathological immune response upon …

[HTML][HTML] Evolving approaches to profiling the microbiome in skin disease

Y Chen, R Knight, RL Gallo - Frontiers in Immunology, 2023 - frontiersin.org
Despite its harsh and dry environment, human skin is home to diverse microbes, including
bacteria, fungi, viruses, and microscopic mites. These microbes form communities that may …

The influence of skin microorganisms on cutaneous immunity

Y Belkaid, S Tamoutounour - Nature Reviews Immunology, 2016 - nature.com
The skin is a complex and dynamic ecosystem that is inhabited by many microorganisms.
Recent evidence highlights the profound reliance of the skin immune system on its resident …

[HTML][HTML] Resistance against Leishmania major infection depends on microbiota-guided macrophage activation

ME Lopes, LM Dos Santos, D Sacks, LQ Vieira… - Frontiers in …, 2021 - frontiersin.org
Innate immune cells present a dual role during leishmaniasis: they constitute the first line of
host defense but are also the main host cells for the parasite. Response against the infection …

Commensal microbiota modulate gene expression in the skin

JS Meisel, G Sfyroera, C Bartow-McKenney, C Gimblet… - Microbiome, 2018 - Springer
Background The skin harbors complex communities of resident microorganisms, yet little is
known of their physiological roles and the molecular mechanisms that mediate cutaneous …

Mechanisms of microbe-immune system dialogue within the skin

N Lunjani, S Ahearn-Ford, FS Dube, C Hlela… - Genes & …, 2021 - nature.com
The prevalence and severity of dermatological conditions such as atopic dermatitis have
increased dramatically during recent decades. Many of the factors associated with an …

Crosstalk between skin microbiota and immune system in health and disease

Q Liu, R Ranallo, C Rios, EA Grice, K Moon… - Nature …, 2023 - nature.com
The US National Institute of Allergy and Infectious Diseases hosted a two-day virtual
workshop on skin microbial communities and their interactions with the host immune system …

[PDF][PDF] The skin microbiota: balancing risk and reward

L Flowers, EA Grice - Cell host & microbe, 2020 - cell.com
The skin microbiome is an ecosystem comprised of a multitude of microbial species
interacting with their surroundings, including other microbes and host epithelial and immune …

The microbiological signature of human cutaneous leishmaniasis lesions exhibits restricted bacterial diversity compared to healthy skin

VR Salgado, ATL Queiroz, SS Sanabani… - Memorias do Instituto …, 2016 - SciELO Brasil
Localised cutaneous leishmaniasis (LCL) is the most common form of cutaneous
leishmaniasis characterised by single or multiple painless chronic ulcers, which commonly …