Monoamine transporter contributions to l-DOPA effects in hemi-parkinsonian rats

MM Conti, SM Meadows, M Melikhov-Sosin… - …, 2016 - Elsevier
Abstract l-DOPA is the standard treatment for Parkinson's disease (PD), but chronic
treatment typically leads to abnormal involuntary movement or dyskinesia (LID) …

Striatal serotonin transporter gain-of-function in L-DOPA-treated, hemi-parkinsonian rats

MMC Mazza, A Centner, DF Werner, C Bishop - Brain research, 2023 - Elsevier
L-DOPA is the standard treatment for Parkinson's disease (PD), but chronic treatment
typically leads to L-DOPA-induced dyskinesia (LID). LID involves a complex interaction …

Effect of tricyclic antidepressants on L-DOPA-induced dyskinesia and motor improvement in hemi-parkinsonian rats

MM Conti, AAA Goldenberg, A Kuberka… - Pharmacology …, 2016 - Elsevier
Although dopamine replacement therapy with L-DOPA in Parkinson's disease initially
reduces motor symptoms, its chronic use often leads to the development of abnormal …

Serotonin transporter inhibition attenuates l‐DOPA‐induced dyskinesia without compromising l‐DOPA efficacy in hemi‐parkinsonian rats

C Bishop, JA George, W Buchta… - European Journal of …, 2012 - Wiley Online Library
Long‐term dopamine replacement therapy with l‐DOPA in Parkinson's disease often leads
to the development of abnormal involuntary movements known as l‐DOPA‐induced …

Effects of prolonged selective serotonin reuptake inhibition on the development and expression of L-DOPA-induced dyskinesia in hemi-parkinsonian rats

MM Conti, CY Ostock, D Lindenbach, AA Goldenberg… - …, 2014 - Elsevier
Dopamine (DA) replacement therapy with l-DOPA is the standard treatment for Parkinson's
disease (PD). Unfortunately chronic treatment often leads to the development of abnormal …

l‐DOPA‐induced dopamine efflux in the striatum and the substantia nigra in a rat model of Parkinson's disease: temporal and quantitative relationship to the …

HS Lindgren, DR Andersson… - Journal of …, 2010 - Wiley Online Library
J. Neurochem.(2010) 112, 1465–1476. Abstract l‐DOPA‐induced dyskinesia in Parkinson's
disease is associated with large increases in brain dopamine (DA) levels following drug …

[HTML][HTML] Serotonergic Regulation of Synaptic Dopamine Levels Mitigates L-DOPA-Induced Dyskinesia in a Mouse Model of Parkinson's Disease

YH Chen, TT Kuo, V Wang, PW Cheng… - Journal of Parkinson's … - content.iospress.com
Background: The serotonin (5-HT) system can manipulate the processing of exogenous L-
DOPA in the DA-denervated striatum, resulting in the modulation of L-DOPA-induced …

Norepinephrine transporter inhibition with desipramine exacerbates L-DOPA–induced dyskinesia: Role for synaptic dopamine regulation in denervated nigrostriatal …

T Chotibut, V Fields, MF Salvatore - Molecular pharmacology, 2014 - ASPET
Pharmacological dopamine (DA) replacement with Levodopa [L-dihydroxyphenylalanine (L-
DOPA)] is the gold standard treatment of Parkinson's disease (PD). However, long-term L …

Effect of serotonin transporter blockade on L-DOPA-induced dyskinesia in animal models of Parkinson's disease

C Fidalgo, WKD Ko, E Tronci, Q Li, R Stancampiano… - Neuroscience, 2015 - Elsevier
Serotonin transporter blockade with selective serotonin reuptake inhibitors (SSRIs) was
recently shown to counteract L-DOPA-induced dyskinesia in 6-hydroxydopamine (6-OHDA) …

Reuptake of L‐DOPA‐derived extracellular DA in the striatum of a rodent model of Parkinson's disease via norepinephrine transporter

A Arai, M Tomiyama, K Kannari, T Kimura, C Suzuki… - Synapse, 2008 - Wiley Online Library
To determine the role of norepinephrine transporter in reuptake of l‐DOPA‐derived
extracellular DA in the DA‐denervated Parkinsonian striatum, we examined extracellular DA …