[HTML][HTML] Decreased MEF2A expression regulated by its enhancer methylation inhibits autophagy and may play an important role in the progression of Alzheimer's …

H Li, F Wang, X Guo, Y Jiang - Frontiers in neuroscience, 2021 - frontiersin.org
Alzheimer's disease (AD) is a neurodegenerative disease characterized by amyloid plaques
and neurofibrillary tangles which significantly affects people's life quality. Recently, AD has …

A Study on Autophagy Related Biomarkers in Alzheimer's Disease Based on Bioinformatics

J Li, W Liu, W Sun, X Rao, X Chen, L Yu - Cellular and Molecular …, 2023 - Springer
Alzheimer's disease (AD) is a neurodegenerative disease with an annual incidence
increase that poses significant health risks to people. However, the pathogenesis of AD is …

[HTML][HTML] An Exploration of the Coherent Effects between METTL3 and NDUFA10 on Alzheimer's Disease

L Yang, X Pang, W Guo, C Zhu, L Yu, X Song… - International Journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disorder characterized primarily by a
decline in cognitive function. However, the etiopathogenesis of AD is unclear. N6 …

[HTML][HTML] MEF2C ameliorates learning, memory, and molecular pathological changes in Alzheimer's disease in vivo and in vitro: Neuroprotective effects of MEF2C

J Ren, S Zhang, X Wang, Y Deng, Y Zhao… - Acta Biochimica et …, 2022 - ncbi.nlm.nih.gov
Myocyte enhancer factor 2C (MEF2C) is highly expressed in the nervous system, and
regulates neuro-development, synaptic plasticity, and inflammation. However, its …

[HTML][HTML] Construction and evaluation of Alzheimer's disease diagnostic prediction model based on genes involved in mitophagy

Y Pei, S Chen, F Zhou, T Xie, H Cao - Frontiers in Aging Neuroscience, 2023 - frontiersin.org
Alzheimer's disease (AD) is a common neurodegenerative disease. The concealment of the
disease is the difficulty of its prevention and treatment. Previous studies have shown that …

[HTML][HTML] Identification of the function and mechanism of m6A reader IGF2BP2 in Alzheimer's disease

Y Deng, H Zhu, L Xiao, C Liu, YL Liu, W Gao - Aging (Albany NY), 2021 - ncbi.nlm.nih.gov
Alzheimer's disease, the most common form of dementia in the elderly, is a kind of
neurodegenerative disease. However, its pathogenesis and diagnosis remain unclear. M6A …

[HTML][HTML] A critical role of autophagy in regulating microglia polarization in neurodegeneration

M Jin, F Wang, DI Qi, W Liu, C Gu, CJ Mao… - Frontiers in Aging …, 2018 - frontiersin.org
Neuroinflammation and autophagy dysfunction are closely related to the development of
neurodegeneration such as Parkinson's disease (PD). However, the role of autophagy in …

Disruption of chaperone-mediated autophagy-dependent degradation of MEF2A by oxidative stress-induced lysosome destabilization

L Zhang, Y Sun, M Fei, C Tan, J Wu, J Zheng, J Tang… - Autophagy, 2014 - Taylor & Francis
Oxidative stress has been implicated in both normal aging and various neurodegenerative
disorders and it may be a major cause of neuronal death. Chaperone-mediated autophagy …

[HTML][HTML] Promoter hypomethylation of TGFBR3 as a risk factor of alzheimer's disease: an integrated epigenomic-transcriptomic analysis

H Song, J Yang, W Yu - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
Alzheimer's disease (AD) is characterized by the abnormal deposition of amyloid-β (Aβ)
plaques and tau tangles in the brain and accompanied with cognitive impairment. However …

[HTML][HTML] MEF2C rs190982 polymorphism with late-onset Alzheimer's disease in Han Chinese: a replication study and meta-analyses

SS Tang, HF Wang, W Zhang, LL Kong, ZJ Zheng… - Oncotarget, 2016 - ncbi.nlm.nih.gov
The myocyte enhancer factor (MEF2) family of transcription factors plays a vital role in
memory and learning due to its functions in regulating synapse number and reducing …