Impact of prior dengue virus infection on Zika virus infection during pregnancy in marmosets

IJ Kim, MP Tighe, MJ Clark, GD Gromowski… - Science Translational …, 2023 - science.org
Zika virus (ZIKV) infection during pregnancy causes severe developmental defects in
newborns, termed congenital Zika syndrome (CZS). Factors contributing to a surge in ZIKV …

Exacerbated Zika virus–induced neuropathology and microcephaly in fetuses of dengue-immune nonhuman primates

WAA Saron, K Shanmugam, CC Tung… - Science Translational …, 2023 - science.org
Zika virus (ZIKV) is a mosquito-borne flavivirus that can vertically transmit from mother to
fetus, potentially causing congenital defects, including microcephaly. It is not fully …

Previous exposure to dengue virus is associated with increased Zika virus burden at the maternal-fetal interface in rhesus macaques

CM Crooks, AM Weiler, SL Rybarczyk… - PLoS neglected …, 2021 - journals.plos.org
Concerns have arisen that pre-existing immunity to dengue virus (DENV) could enhance
Zika virus (ZIKV) disease, due to the homology between ZIKV and DENV and the …

[HTML][HTML] Cross-reactive dengue virus antibodies augment Zika virus infection of human placental macrophages

MG Zimmerman, KM Quicke, JT O'Neal, N Arora… - Cell host & …, 2018 - cell.com
Zika virus (ZIKV), which emerged in regions endemic to dengue virus (DENV), is vertically
transmitted and results in adverse pregnancy outcomes. Antibodies to DENV can cross-react …

In-depth characterization of congenital Zika syndrome in immunocompetent mice: Antibody-dependent enhancement and an antiviral peptide therapy

VN Camargos, G Foureaux, DC Medeiros… - …, 2019 - thelancet.com
Background Zika virus (ZIKV) infection during pregnancy may cause major congenital
defects, including microcephaly, ocular, articular and muscle abnormalities, which are …

Zika virus infection in human placental tissue explants is enhanced in the presence of dengue virus antibodies in-vitro

K Hermanns, C Göhner, A Kopp, A Schmidt… - Emerging microbes & …, 2018 - Taylor & Francis
The current Zika virus (ZIKV) outbreak is associated with neurological malformations and
disorders in neonates. Areas of increased incidence of malformations may overlap with …

Differential gene expression elicited by ZIKV infection in trophoblasts from congenital Zika syndrome discordant twins

MS Amaral, E Goulart, LC Caires-Júnior… - PLoS Neglected …, 2020 - journals.plos.org
Zika virus (ZIKV) causes congenital Zika syndrome (CZS), which is characterized by fetal
demise, microcephaly and other abnormalities. ZIKV in the pregnant woman circulation must …

Control of maternal Zika virus infection during pregnancy is associated with lower antibody titers in a macaque model

NP Krabbe, E Razo, HJ Abraham, RV Spanton… - Frontiers in …, 2023 - frontiersin.org
Introduction Zika virus (ZIKV) infection during pregnancy results in a spectrum of birth
defects and neurodevelopmental deficits in prenatally exposed infants, with no clear …

Comparative analysis of in vitro models to study antibody-dependent enhancement of Zika virus infection

T Langerak, N Mumtaz, M Koopmans, S Schoenmakers… - Viruses, 2022 - mdpi.com
During the 2015–2016 outbreak of Zika virus (ZIKV) in the Americas, a previously unknown
severe complication of ZIKV infection during pregnancy resulting in birth defects was …

Dengue virus immunity increases Zika virus-induced damage during pregnancy

JA Brown, G Singh, JA Acklin, S Lee, JE Duehr… - Immunity, 2019 - cell.com
Zika virus (ZIKV) has recently been associated with birth defects and pregnancy loss after
maternal infection. Because dengue virus (DENV) and ZIKV co-circulate, understanding the …