G protein-coupled receptors (GPCRs) are involved in numerous key neurotransmitter
systems in the brain that are disrupted in Alzheimer's disease (AD). GPCRs also directly …

Highlights•GPCRs are implicated in the pathophysiology of various neurodegenerative
diseases.•Currently available therapies do not cure the discussed neurodegenerative …

Overwhelming evidence indicates that the effects of β-amyloid (Aβ) are dose dependent
both in vitro and in vivo, which implies that Aβ is not directly detrimental to brain cells until it …

Neuropsychiatric disorders are multifactorial disorders with diverse aetiological factors.
Identifying treatment targets is challenging because the diseases are resulting from …

Neurodegenerative diseases are a large group of neurological disorders with diverse
etiological and pathological phenomena. However, current therapeutics rely mostly on …

G protein-coupled receptors (GPCRs) play pivotal roles in regulating the function and
plasticity of neuronal circuits in the nervous system. Among the myriad of GPCRs expressed …

The orphan G protein (heterotrimeric guanine nucleotide–binding protein)–coupled receptor
(GPCR) GPR3 regulates activity of the γ-secretase complex in the absence of an effect on …

Cells translate extracellular signals to regulate processes such as differentiation,
metabolism and proliferation, via transmembranar receptors. G protein-coupled receptors …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that affects 36 million
people worldwide, but currently has no effective treatment options. One of the original …

Although the molecular mechanisms underlying psychiatric illnesses such as depression,
bipolar disorder and schizophrenia remain incompletely understood, there is increasing …